2015, Number 5
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Ann Hepatol 2015; 14 (5)
Hepatology highlights
Gambaro SE, Giraudi PJ, Tiribelli C, Rosso N
Language: English
References: 4
Page: 616-617
PDF size: 74.06 Kb.
Text Extraction
Sutter,
et al.
Development of steatohepatitis in Ob/Ob mice is
dependent on Toll-like receptor 4
Sutter,
et al. Studies in animals models and
human subjects have suggested that leptin signaling
may play a causal role in the development of steatohepatitis
perpetuating the inflammatory state. However,
clinical observations have been conflicting,
since serum leptin was linked neither to necroinflammatory
grade and the fibrosis stage.
REFERENCES
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Liu J, Zhuang ZJ, Bian DX, Ma XJ, Xun YH, Yang WJ, Luo Y, et al. Toll-like receptor-4 signalling in the progression of nonalcoholic fatty liver disease induced by high-fat and high-fructose diet in mice. Clin Exp Pharmacol Physiol 2014; 41: 482-8.
Sharifnia T, Antoun J, Verriere TG, Suarez G, Wattacheril J, Wilson KT, Peek RM Jr, et al. Hepatic TLR4 Signaling in Obese NAFLD. Am. J. Physiol. Gastrointest. Liver Physiol. ajpgi.00304.2014 (2015). doi:10.1152/ajpgi.00304. 2014
Chatani N, Kamada Y, Kizu T, Ogura S, Furuta K, Egawa M, Hamano M, et al. Secreted frizzled-related protein 5 (Sfrp5) decreases hepatic stellate cell activation and liver fibrosis. Liver Int Off J Int Assoc Study Liver (2014). doi:10.1111/liv.12757