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2015, Number 2

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Rev cubana med 2015; 54 (2)

Urinary pH and nutritional status in Cuban ptients with urolithiasis

Bacallao MRA, Mañalic CR, Gutiérrez GF, Badell MA, Caldevilla RY

Language: Spanish
References: 27
Page: 119-128
PDF size: 131.87 Kb.


ABSTRACT

Introduction: obesity and urolithiasis are growing problems in the world. The acid (low) urinary pH predisposes urolithiasis.
Objective: determine the possible relationship between body weight and body mass index (BMI) with urinary pH in patients with kidney stones.
Methods: a cross-sectional observational study was conducted in all Cuban adults lithiasic patients who underwent renal metabolic study at the Nephrology Institute from January 2011 to December 2012, and who did not have any conditions with recognized influence on urinary pH. Urinary pH was measured and a mini-culture was performed on a fasting urine sample. Weight, height and body mass index were registered. The information was processed using SPSS version 15.0. Mean age, standard deviation of minimum and maximum age, weight and body mass index were calculated. Comparisons between variables were made by analysis of variance.
Results: 1 724 patients were studied with age average of 41.6 years and a male/female ratio of 2.1/1. The urinary pH mean decreased 0.23 sextile units from less to heavier body weight (p= 0.00). The urinary pH mean was 5.69 in malnourished and normal weight patients, it was 5.59 in overweight patients, and 5.53 in those obese (p= 0.00).
Conclusion: fasting urinary pH is inversely related to body weight and body mass index in adult patients with urinary lithiasis without infection of the urinary tract.


REFERENCES

  1. Schneider H, Dietrich E, Venetz W. Trends and Stabilization up to 2022 in Overweight and Obesity in Switzerland, Comparison to France, UK, US and Australia. Int J Environl Res Public Health. 2010;7(2):460-72.

  2. Jiménez Acosta S, Díaz ME, Barroso I, Bonet M, Cabrera A, Wong I. Estado nutricional de la población cubana adulta. Rev Esp Nutr Comunitaria. 2005;11(1):18-26.

  3. Porrata C, Suárez A, Hernández M, Jiménez S, Argüelles J, Cabrera A, et al. Dieta y salud en Cuba. Arch Latin Nutr. 1995;45(1-S):214-19.

  4. Vila-Bedmar R, Fernández-Veledo S. A new era for brown adipose tissue: New insights into brown adipocyte function and differentiation. Archives of Physiology and Biochemistry. 2011;117:195-208.

  5. Alberti K, Zimmet P, Shaw J. The metabolic syndrome a new worldwide definition. Lancet. 2005;366(9491):1059-62.

  6. Shin JA, Lee JH, Lim SY, Ha HS, Kwon HS, Park YM, et al. Metabolic syndrome as a predictor of type 2 diabetes, and its clinical interpretations and usefulness. J Diabetes Investig. 2013 Jul 8;4(4):334-43.

  7. Stamatelou KK, Francis ME, Jones CA. Time trends in reported prevalence of kidney stones in the United States: 1976-1994. Kidney Int. 2003;63:1817-23.

  8. Reyes L, Almaguer M, Castro T. Estudio clínico-epidemiológico de la urolitiasis en un área urbana caribeña. Nefrología. 2002;22:239-44.

  9. Curhan GC, Willett WC, Rimm EB, Speizer FE, Stampfer MJ. Body size and risk of kidney stones. J Am Soc Nephrol. 1998;9:1645-52.

  10. Taylor EN, Stampfer MJ, Curhan GC. Obesity, weight gain, and the risk of kidney stones. JAMA. 2005;293(4):455-62.

  11. Kamel K, Cheema-Dhadli S, Shafiee M, Davids M, Halperin M. Recurrent uric acid stones. Q J Med. 2005;98:57-68.

  12. Zerifi R, Bahlous A, Marakchi O, Daudon M, Bartagi Z, Abdelmoula J. Syndrome métabolique: physiopathologie et impact sur la lithogenèse. Ann Biol Clin. 2008;66(1):9-17.

  13. Bushinsky DA, Coe FL, Moe OW. Nephrolithiasis. En: Taal MW, Chertow GM, Marsden PA, Skorecki K, Yu ASL, Brenner BM, editores. The Kidney. 9 ed. Philadelphia: Elsevier Health Sciences; 2011. Pp. 1455-507.

  14. WHO. World Health Organization. Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee. WHO Technical Report Series 854. Geneva: World Health Organization; 1995.

  15. Seitz C, Fajkovic H. Epidemiological gender-specific aspects in urolithiasis. World J Urol. Oct. 2013;31(5):1087-92.

  16. Trinchieri A. Epidemiology of urolithiasis: an update. Clin Cases Miner Bone Metab. May 2008;5(2):101-6.

  17. Maalouf NM, Sakhaee K, Parks JH, Coe FL, Adams-Huet B, Pak CY. Association of urinary pH with body weight in nephrolithiasis. Kidney Int. 2004;65(4):1422-5.

  18. Najeeb Q, Masood I, Bhaskar N, Kaur H, Singh J, Pandey R, et al. Effect of BMI and urinary pH on urolithiasis and its composition. Saudi J Kidney Dis Transpl. 2013 Jan;24(1):60-6.

  19. Yao X, Forte JG. Cell biology of acid secretion by the parietal cell. Annu Rev Physiol. 2003;65:103.

  20. Heymsfield SB, Adamek M, Gonzalez MC, Jia G, Thomas DM. Assessing skeletal muscle mass: historical overview and state of the art. J Cachexia Sarcopenia Muscle. 2014 Mar;5(1):9-18.

  21. Li WM, Chou YH, Li CC, Liu CC, Huang SP, Wu WJ, et al. Association of body mass index and urine pH in patients with urolithiasis. Urol Res. 2009 Aug;37(4):193-6.

  22. Chobanian MC, Hammerman MR. Insulin stimulates ammoniagenesis in canine renal proximal tubular segments. Am J Physiol. 1977;253:171-7.

  23. Gesek FA, Schoolwerth AC. Insulin increases Na+/H+ exchange activity in proximal tubules from normotensive and hypertensive rats. Am J Physiol. 1991;260:695-703.

  24. Abate N, Chandalia M, Cabo-Chan AV Jr, Moe OW, Sakhaee K. The metabolic syndrome and uric acid nephrolithiasis: novel features of renal manifestation of insulin resistance. Kidney Int. 2004;65:386-92.

  25. Cameron MA, Maalouf NM, Adams-Huet B, Moe OW, Sakhaee K. Urine composition in type 2 diabetes: predisposition to uric acid nephrolithiasis. J Am Soc Nephrol. 2006;17:1422-8.

  26. Chung SD, Chen YK, Lin HC. Increased risk of diabetes in patients with urinary calculi: a 5-year followup study. J Urol. 2011 Nov;186(5):1888-93.

  27. Marickar F, Salim A. Temporary risk identification in urolithiasis. Urol Res. 2009;37(6):377-80.




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