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2015, Number 2

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Rev cubana med 2015; 54 (2)

Mortality causes in Hodgkin lymphoma patients

Delgado VT, Carnot UJ, de Castro AR, Muñío PJ, Hernández CC, Núñez QA, Pérez RG, Rodriguez FY

Language: Spanish
References: 35
Page: 107-118
PDF size: 160.89 Kb.


ABSTRACT

Objective: determine the causes of death in patients diagnosed with Hodgkin lymphoma.
Methods: a retrospective descriptive study was conducted at the Department of Hematology, “Hermanos Ameijeiras” Hospital. The sample was composed of 443 patients, 619 diagnosed from January 1983 to December 2008. 287 of them (64.8 %) were alive at the end of the study, 156 (35.2 %) had died.
Results: the relapse/progression of Hodgkin lymphoma was the most important cause of death (125 patients, 80 %), regardless of the age of the disease onset, the type of treatment used and the time of evolution. The remaining 20 % was due to: second malignancies in 10 patients (6.4 %), complications of treatment in 8 (5.1 %), fatal infectious complications in 2 (1.2 %) and cardiovascular disease in 3 (1.9 %). In 8 patients (5.1 %) the cause of death was not specified. Secondary malignancies prevailed in patients aged 40-59 years who received combined treatment and had less than 10 years of evolution.
Conclusions: relapse/progression of Hodgkin lymphoma remains a leading cause of death, regardless of the onset age, the treatment modality used and the time of evolution. It would be important to identify early cases refractory to conventional treatment to use the most appropriate therapeutic modality for healing.


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