2012, Number 5
<< Back Next >>
Ann Hepatol 2012; 11 (5)
Review of the neurological manifestations of hepatitis E infection
Cheung MCM, Maguire J, Carey I, Wendon J, Agarwal K
Language: English
References: 29
Page: 618-622
PDF size: 79.25 Kb.
Text Extraction
Hepatitis E (HEV) is a common infection worldwide and is an emerging disease in developed countries. The presence of extra-hepatic manifestation of HEV infection is important to bear in mind so that the diagnosis is not missed, since HEV is not routinely tested for in acute hepatitis due to perceived rarity of this infection outside of endemic countries. This article reviews the neurological presentations of acute and chronic HEV, and discusses the viral kinetics against symptomatology, and outcomes of specific treatment. Possible mechanisms of pathogenesis are considered.
REFERENCES
Dalton HR, Bendall R, Ijaz S, Banks M. Hepatitis E: an emerging infection in developed countries. Lancet Infect Dis 2008; 8: 698-709.
Purcell RH, Emerson SU. Hepatitis E: an emerging awareness of an old disease. J Hepatol 2008; 48: 494-503.
Amarapurkar DN, Amarapurkar AD. Extrahepatic manifestations of viral hepatitis. Ann Hepatol 2002; 1: 192-5.
Kamar N, Izopet J, Cintas P, Garrouste C, Uro-Coste E, Cointault O, Rostaing L. Hepatitis E virus-induced neurological symptoms in a kidney-transplant patient with chronic hepatitis. Am J Transplant 2010; 10: 1321-4.
Fourquet E, Mansuy JM, Bureau C, Recher C, Izopet J, Peron JM. Severe thrombocytopenia associated with acute autochthonous hepatitis E. J Clin Virol 2010; 48: 73-4.
Kamar N, Bendall RP, Peron JM, Cintas P, Prudhomme L, Masuy JM, Rostaing L, et al. Hepatitis E virus and neurologic disorders. Emerg Infect Dis 2011; 17: 173-9.
Sood A, Midha V, Sood N. Guillain-Barre syndrome with acute hepatitis E. Am J Gastroenterol 2000; 95: 3667-8.
Kamani P, Baijal R, Amarapurkar D, Gupte P, Patel N, Kumar P, Agal S. Guillain-Barre syndrome associated with acute hepatitis E. Indian J Gastroenterol 2005; 24: 216.
Maurissen I, Jeurissen A, Strauven T, Sprengers D, De Schepper B. First case of anti-ganglioside GM1-positive Guillain-Barre syndrome due to hepatitis E virus infection. Infection 2011 [Epub].
Loly JP, Rikir E, Seivert M, Legros E, Defrance P, Belaiche J, Moonen G, et al. Guillain-Barre syndrome following hepatitis E. World J Gastroenterol 2009; 15: 1645-7.
Cronin S, McNicholas R, Kavanagh E, Reid V, O’Rourke K. Anti-glycolipid GM2-positive Guillain-Barre syndrome due to hepatitis E infection. Ir J Med Sci 2011; 180: 255-7.
Khanam RA, Faruq MO, Basunia RA, Ahsan ASM. Guillain-Barre syndrome associated with acute HEV hepatitis. Ibrahim Med Coll J 2008; 2: 32-4.
Kumar R, Bhoi S, Kumar M, Sharma B, Singh BM, Gupta BB. Guillain-Barre syndrome and acute hepatitis E: a rare association. JIACM 2002; 3: 389-91.
Cheung MC, Maguire J, Carey I, Wendon J, Agarwal K. Hepatitis E-an unexpected problem at home. Scand J Gastroenterol 2012; 47: 253 [letter to editor].
Fong F, Illahi M. Neuralgic amyotrophy associated with hepatitis E virus. Clin Neurol Neurosurg 2009; 111: 193-5.
Despierres LA, Kaphan E, Attarian S, Cohen-Bascrie S, Pelletier J, Pouget J, Motte A, et al. Neurologic disorders and hepatitis E, France, 2010. Emerg Infect Dis 2011; 17: 1510-2.
Mandal K, Chopra N. Acute transverse myelitis following hepatitis E virus infection. Indian Pediatr 2006; 43: 365-6.
Tse ACT, Cheung RTF, Ho SL, Chan KH. Guillain-Barre syndrome associated with acute hepatitis E infection. J Clin Neurosci 2012; 19: 607-8.
Inghilleri ML, Grini Mazouzi M, Juntas Morales R. Neuralgic amyotrophy as a manifestation of hepatitis E infection. Rev Neurol (Paris) 2012; 168: 383-4.
Rianthavorn P, Thongmee C, Limpaphayom N, Komolmit P, Theamboonlers A, Poovorawan Y. The entire genome sequence of hepatitis E virus genotype 3 isolated from a patient with neuralgic amyotrophy. Scan J Infect Dis 2010; 42: 395-400.
Yadav KK, Rohatgi A, Sharma SK, Kulshrestha M, Sachdeva S, Pardasani V. Oculomotor palsy associated with hepatitis E infection. J Assoc Physicians India 2002; 50: 737.
Kejariwal D, Roy S, Sarkar N. Seizure associated with acute hepatitis E. Neurology 2001; 57: 1935.
Thapa R, Mallick D, Biswas B. Psudotumor cerebri in childhood hepatitis E virus infection. Headache 2009; 49: 610-1.
Dixit VK, Abhilash VB, Kate MP, Jain AK. Hepatitis E infection with Bell’s palsy. J Assoc Physicians India 2006; 54: 418.
Van Doorn PA, Ruts L, Jacobs BC. Clinical features, pathogenesis, and treatment of Guillain-Barre syndrome. Lancet Neurol 2008; 7: 939-50.
Haagsma EB, Riezebos-Brilman A, Van den Berg AP, Porte RJ, Niesters HG. Treatment of chronic hepatitis E in liver transplant recipients with pegylated interferon alpha-2b. Liver Transpl 2010; 16: 474-7.
Kamar N, Rostaing L, Abravenel F, Garrouste C, Esposito L, Cardeau-Desangles I, Mansuy JM, et al. Pegylated interferonalpha for treating chronic hepatitis E virus infection after liver transplantation. Clin Infect Dis 2010: 50: e30-e33.
Kusunoki S, Kaida K. Antibodies against ganglioside complexes in Guillain-Barre syndrome and related disorders. J Neurochem 2011; 116: 828-32.
Van Alfen N. Clinical and patholophysiological concepts of neuralgic amyotrophy. Nat Rev Neurol 2011; 7: 315-22.