2012, Number 4
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Ann Hepatol 2012; 11 (4)
Pegylated interferon, but not conventional interferon therapy induced severe skin lesions
Zhengxiao L, Fanpu J, Yan Z, Jingang A, Zhenhui P
Language: English
References: 6
Page: 570-571
PDF size: 83.83 Kb.
Text Extraction
Dear Editor:
Pegylation is an important technique that has
greatly improved the pharmacologic profile of interferon.
Compared with conventional interferon(IFN)-α
injections, pegylated interferon (PEG-IFN) has a
longer half-life allowing for once-weekly injections
and superior antiviral efficacy in the treatment of
hepatitis C when used in combination with ribavirin. However, cutaneous side effects had been reported
more frequent with PEG-IFN. We present a
patient with chronic hepatitis C (CHC) in whom
PEG-IFN, but not conventional interferon therapy
induced severe skin lesions at the sites of injection.
REFERENCES
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Edwards IR, Aronson JK. Adverse drugs reactions: definitions, diagnosis, and management. Lancet 2000; 356: 1255-9.
Dereure O, Raison-Peyron N, Larrey D, Blanc F, Guilhou JJ. Diffuse inflammatory lesions in patients treated with interferon alfa and ribavirin for hepatitis C: a series of 20 patients. Br J Dermatol 2002; 147: 1142-6.
Lübbe J, Kerl K, Negro F, Saurat JH. Clinical and immunological features of hepatitis C treatment associated dermatitis in 36 prospective cases. Br J Dermatol 2005; 153: 1088-90.
Hashimoto Y, Kanto H, Itoh M. Adverse skin reactions due to pegylated interferon alpha 2b plus ribavirin combination therapy in a patient with chronic hepatitis C virus. J Dermatol 2007; 34: 577-82.
Veldt BJ, Schalm SW, Janssen HL. Severe allergic eczema due to pegylated alfa interferon may abate after switching to daily conventional alfa-interferon. J Clin Gastroenterol 2007; 41: 432.