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2015, Number 2

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Rev Cuba Endoc 2015; 26 (2)

Immune mechanisms and female infertility

León TEJ, Hernández DEB, Cubas DI, Rodríguez AJ, Cabrera-Rode E

Language: Spanish
References: 37
Page: 193-205
PDF size: 168.02 Kb.


ABSTRACT

Introduction: infertility is a growing worldwide health problem whose causal factors are mostly associated to the female sex. A close relationship has recently been suggested between fertility disorders and functional alterations of the immune system contributing to and maintaining infertility.
Objective: review updated scientific literature about the subject to identify the role of immune mechanisms in the development of female infertility.
Development: the very immune components ensuring the success of reproduction may create a perpetuated inflammatory environment in the presence of an antigenic stimulus, resulting in the development of a tissular lesion. Dysregulated inflammation triggers autoimmune reactions against reproductive structures, affecting their operation. The presence of autoantibodies and proinflammatory cytokines as biological markers of these phenomena has been reported for conditions such as endometriosis and polycystic ovary syndrome.
Conclusions: the immune system is known to play an important role in both normal and pathological female reproduction. However, information about the subject continues to be scant. Underestimation of the immune factors present in the clinical environment often blocks the way for diagnostic and therapeutic alternatives which could otherwise improve the quality of the care of infertile women. The complexity of the immune and endocrine systems, as well as the limited reach of the available diagnostic tools, are factors contributing to such insufficiency.


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