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2015, Number 2

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Rev Cuba Endoc 2015; 26 (2)

Climacteric stages and endothelial function in middle-aged women

Sariol CY, Navarro DD, Álvarez PR, de Armas ÁY, Domínguez AE, Dopazo AM

Language: Spanish
References: 32
Page: 138-146
PDF size: 160.53 Kb.


ABSTRACT

Introduction: estrogen reduction during the climacteric has a negative effect on the vascular endothelium and causes endothelial dysfunction, whose clinical significance is still to be defined.
Objective: determine the frequency of endothelial dysfunction in the different stages of climacteric.
Methods: a descriptive cross-sectional study was conducted of 133 women aged 40-59 with no cardiovascular risk factors, selected from institutions of the three health care levels within the National Health System from May 2012 to May 2013. Endothelial function was evaluated using the brachial artery flow-mediated dilation test and its association with climacteric stages. The relationship between variables was analyzed using non-parametric tests (Kruskal-Wallis).
Results: 38 % of the women had endothelial dysfunction, which was more common in the early stage of post-menopause than in the late stage and in perimenopause (45.0 vs. 27.5 vs. 27.5 %, respectively [p ‹ 0.05]).
Conclusions: endothelial dysfunction is a common event among seemingly healthy middle-aged women. It seems that the initial reduction in estrogens in the first years of post-menopause has a greater negative impact on the vascular endothelium than the time of exposure to hypoestrogenism.


REFERENCES

  1. Capote MI, Segredo AM, Gómez O. Climaterio y menopausia. Rev Cubana Med Gen Integr. 2011;27(4):543-57.

  2. Sarduy M, Lugones M. II Consenso Cubano de Climaterio y Menopausia. Capítulo 1 La Habana: CIMEQ; 2007. p. 15.

  3. Dessapt AL, Gourdy P. Menopause and cardiovascular risk. J Gynecol Obstet Biol Reprod. 2012;41(7):13-9.

  4. Matthews K, Sutton-Tyrrell K. ¿Qué hay de nuevo acerca de la menopausia y el riesgo cardiovascular? Revista del Climaterio. 2011;14(81):80-4.

  5. Mendelsohn ME. Efectos de los estrógenos en el sistema cardiovascular. Revista del Climaterio. 2010;13(74):56-60.

  6. Hernández M, Blanco O. Los estrógenos como protectores cardiovasculares. Medicentro Electrónica. 2012;16(3):148-53.

  7. Simón A, Castro A, Kaski J. Avances en el conocimiento de la disfunción endotelial y su aplicación en la práctica clínica. Rev Cubana Med. 2001;40(3):212-22.

  8. Badimón L, Martínez-González J. Disfunción endotelial: Actualización y futuro del óxido nítrico en el tratamiento de la enfermedad cardiovascular. Rev Esp Cardiol Supl. 2006;6(1):21-30.

  9. Zaragoza C, Márquez S, Saura M. Endothelial mechanosensors of shear stress as regulators of atherogenesis. Curr Opin Lipidol. 2012;23(5):446-52.

  10. Sánchez C, Peiró C, Rodríguez-Mañas L. Disfunción endotelial asociada al envejecimiento vascular humano. Clínic Invest Arterioscler. 2011;23(3):135-9.

  11. García D, García R, García J, Concepción A, Peix A. Diagnóstico preclínico de la aterosclerosis: función endotelial. Rev Cubana Med. 2003;42(1):58-63.

  12. Hashimoto M, Miyamoto Y, Matsuda Y, Akita H. New Methods to Evaluate Endothelial Function: Non-invasive Method of Evaluating Endothelial Function in Humans. J Pharmacol Sci. 2003;93(4):405-8.

  13. Markos F, Ruane O'Hora T, Noble MI. What is the mechanism of flow-mediated arterial dilatation. Clin Exp Pharmacol Physiol. 2013;40(8):489-94.

  14. Rossi R, Nuzzo A, Origliani G, Modena M. Prognostic role of flow-mediated dilation and cardiac risk factors in post-menopausal women. J Am Col Cardiol. 2008;51(10):997-1002.

  15. Poredos P, Jezovnik MK. Testing endothelial function and its clinical relevance. J Atheroscler Thromb. 2013;20(1):1-8.

  16. Sánchez M, Granero R, Pompini G. Epidemiología de la enfermedad cardiovascular en la mujer. Enfermedad cardiovascular en la mujer: prevención, diagnóstico y tratamiento. Caracas: Editorial 2 Mundos C.A.; 2011. p. 25-30.

  17. Lloyd-Jones D, Adams RJ, Brown TM, Carnethon M, Dai S, De Simone G, et al. Heart disease and stroke statistics-2010 update: a report from the American Heart Association. Circulation. 2010;121(7):46-215.

  18. Cuba. Ministerio de Salud Pública. Anuario estadístico de salud 2012 [homepage en Internet]; La Habana, Minsap, 2012 [citado 3 de marzo de 2013]. Disponible en: http://files.sld.cu/dne/files/2013/04/anuario_2012.pdf

  19. Navarro D, Céspedes I, Díaz C. Estilos de vida y salud ósea en mujeres de edad mediana. Rev Cubana Endocrinol [serie en Internet]. 2008 [citado 6 de marzo de 2012];19(3). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1561- 29532008000300003&lng=es&nrm=iso&tlng=es

  20. Santana F, Navarro D, Padrón R, Cabrera M. Efectos de la menopausia sobre los niveles de prolactina en mujeres con hiperprolactinemia. Rev Cubana Endocrinol [serie en Internet]. 2007 [citado 6 de marzo de 2012];18(2). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1561- 29532007000200004&lng=es&nrm=iso&tlng=es

  21. Taddei S. La presión arterial en el envejecimiento y la menopausia. Rev Climaterio. 2010;13(74):79-84.

  22. Navarro D. Hormonas del eje hipotálamo-hipófisis gonadal y síndrome climatérico. Rev Cubana Endocrinol [serie en Internet]. 2007 [citado 6 de marzo de 2012];18(3). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1561- 29532007000300003&lng=es&nrm=iso&tlng=es

  23. Kaźmierski M, Michalewska-Włudarczyk A, Krzych LJ. Intima-media thickness and flow-mediated dilatation in the diagnosis of coronary artery disease in perimenopausal women. Pol Arch Med Wewn. 2010;120(5):181-8.

  24. Valdés A, Sixto S. Angina microvascular en mujeres posmenopáusicas. Medisur. 2011;9(5):443-51.

  25. Maeda M, Nakamura C, Uchigaki A, Yuba K, Utsumi M, Siba M, et al. Effects of aging and menopause on women's vascular systems. Nihon Ronen Igakkai Zasshi. 2011;48(2):158-62.

  26. Moreau KL, Hildreth KL, Meditz AL, Deane KD, Kohrt WM. Endothelial function is impaired across the stages of the menopause transition in healthy women. J Clin Endocrinol Metab. 2012;97(12):4692-700.

  27. Shaw LJ, Bugiardini R, Bairey Merz CN. Women and ischemic heart disease: Evolving knowledge. J Am Coll Cardiol. 2009;54(17):1561-75.

  28. Eluf OO, Wllerson N, Mendes J. Interaoes entre estrogenios e endotelio. Endotelio e doencas cardiovasculares. Brasilia: Editorial Atheneu; 2003. p. 281-96.

  29. Bechlioulis A, Kalantaridou SN, Naka KK, Chatzikyriakidou A, Calis KA, Makrigiannakis A, et al. Endothelial function, but not carotid intima-media thickness, is affected early in menopause and is associated with severity of hot flushes. J Clin Endocrinol Metab. 2010;95(3):1199-206.

  30. Wildman RP, Colvin AB, Powell LH, Matthews KA, Everson-Rose SA, Hollenberg S, et al. Associations of endogenous sex hormones with the vasculature in menopausal women: The Study of Women’s Health Across the Nation (SWAN). Menopause. 2008;15(3):414-21.

  31. Kalantaridou SN, Naka KK, Papanikolaou E. Impaired endothelial function in young women with premature ovarian failure: normalization with hormone therapy. J Clin Endocrinol Metab. 2004;89(8):3907-13.

  32. Leuzzi C, Marzullo R, Modena MG. Is menopause a risk factor for ischemic heart disease in women? G Ital Cardiol. 2012;13(6):401-6.




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