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ISSN 1025-0255 (Electronic)

2015, Number 3

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AMC 2015; 19 (3)

Stevens-Johnson's syndrome: presentation of three cases

Váquez CJL, Vázquez SA, Ortiz JY, Brito BM, Vázquez BL

Language: Spanish
References: 16
Page: 271-278
PDF size: 458.43 Kb.


ABSTRACT

Background: Stevens-Johnson’s syndrome (SJS) is a serious disease, fatal most of the time, which has been considered as a type of erythema multiforme. It is generally caused by medicaments. If it is not diagnosed and treated at appropriate time it can be associated to considerable sequelae and death.
Objective: to describe the treatment and evolution of the clinical manifestations of three cases with the diagnosis of Stevens-Johnson’s syndrome admitted in the intensive care unit.
Cases presentation: the cases of two female patients and a male patient with the diagnosis of SJS, associated to the use of medicaments, are briefly presented. The treatment consisted of measures of general care for the prophylaxis and treatment of complications for the three cases. The patients were treated with intravenous IgG of national production (intacglobin) and systemic steroids. The three patients improved their condition satisfactorily.
Results: the use of intravenous immunoglobulin G in the treatment of these patients stands out; as well as the importance of the treatment of seriously ill patients in an intensive care unit.
Conclusions: female sex predominated in the casuistics. The early use of Intacglobin (IgG IV) contributed to a better improvement of the patient’s condition arresting the development of the disease, avoiding complications and decreasing the hospital stay of seriously ill patients.


REFERENCES

  1. Harr T, French LE. Toxic epidermal necroly-sis and Stevens-Johnson Syndrome. Harr and French Orphanet Journal of Rare Dis-eases [Internet]. 2010 diciembre [Citado 24 de Oct 2014];5:39. [aprox. 11 p.]. Dis-ponible en: http://www.ojrd.com/content/5/1/39.

  2. David A. Wetter, MD, and Michael J. Camil-leri, MD. Clinical, Etiologic, and Histopatho-logic Features of Stevens-Johnson Syndrome During an 8-Year Period at Mayo Clinic. Mayo Clin Proc. 2010 febrero;85(2):131-138.

  3. Pedigoni A, Domingues G, Penna H, Delas-cio R, Sandre L; Carlos A. Síndrome de Stevens-Johnson e Necrólise Epidérmica Tóxica em Medicina Intensiva. RBTI 2006 julio-sept;18(3):292-297.

  4. Ward KE, Archambault R, Mersfelder TL. Severe adverse skin reactions to nonsteroi-dal antiinflammatory drugs: A review of the literature. Am J Health Syst Pharm. 2010 febrero;67(3):206-13.

  5. Gerull R, Nelle M, Schaible T. Toxic epider-mal necrolysis and Stevens-Johnson syn-drome: a review. Crit Care Med. 2011 jun-io;39(6):1521-32.

  6. Castana O., Rempelos G., Anagiotos G., Apostolopoulou C., Dimitrouli A., Alexakis D. Stevens-Johnson Syndrome: a case re-port. Annals of Burns and Fire Disasters 2009 septiembre;22(3):147-151.

  7. Quiñones J, Chávez JA, Bernárdez O. Sín-drome de Stevens-Johnson: presentación de un caso. AMC mayo-jun. 2011;15(3): 576-584.

  8. Chen J,Zeng Y,Xu H. High-dose intravenous immunoglobulins in the treatment of Ste-vens-Johnson syndrome and toxic epider-mal necrolysis in Chinese patients: a retro-spective study of 82 cases. 2010 noviembre-dic;20(6):743-7.

  9. Sawicki J, x Jakub SawickiSearch for arti-cles by this author 10. Affiliations

  10. Department of Medicine, University of To-ronto, Toronto, Ontario, Canada

  11. Ellis AK. Stevens-Johnson syndrome: A re-view of 14 adult cases with one fatal out-come. Annals of Allergy, Asthma & Im-munology. 2013 marzo; 110 (3):207–209.e1.

  12. Barron SJ, Del Vecchio MT, Aronoff SC. In-travenous immunoglobulin in the treatment of Stevens-Johnson syndrome and toxic epidermal necrolysis: a meta-analysis with meta-regression of observational studies. International Journal Of Dermatology [Internet]. abril 2014 [citado 24 de Oct 2014];[aprox. 1 p.] http://onlinelibrary.wiley.com/doi/10.1111/ijd.12423/full.

  13. Pozzo-Magana BR, Lazo-Langner A, Car-leton B, Castro-Pastrana L, Rieder M. A systematic review of treatment of drug-induced stevensjohnson Syndrome and toxic epidermal necrolysis in children. J Popul Ther Clin Pharmacol. 2011 marzo;18(1):e121-e133.

  14. Sawicki J, Ellis AK. Stevens-Johnson syn-drome: A review of 14 adult cases with one fatal outcome. Annals of Allergy, Asthma & Immunology. 2013 marzo; 110(3):207–209.e1.

  15. Campagna C, Tassinari D, Neri I, Bernardi F. Mycoplasma pneumoniae-induced recur-rent Stevens-Johnson syndrome in chil-dren: a case report. Pediatr Dermatol. 2013 septiembre-oct;30(5):624-6.

  16. Wetter D, Camilleri M. Clinical, Etiologic, and Histopathologic Features of Stevens-Johnson Syndrome During an 8-Year Period at Mayo ClinicMayo Clin Proc. 2010 febre-ro;85(2):131-138.




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