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ISSN 0185-6014 (Print)
Órgano oficial de difusión de la Federación Mexicana de Patología Clínica, AC y de la Asociación Latinoamericana de Patología Clínica/Medicina de Laboratorio

2002, Number 3

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Rev Mex Patol Clin Med Lab 2002; 49 (3)

Humoral recognition mechanisms in the solid organs xenotransplantation: I. Overview of the hyperacute rejection

Arteaga TG, Guerra-Infante FM

Language: Spanish
References: 60
Page: 130-140
PDF size: 86.86 Kb.


ABSTRACT

Vascularized tissue grafting between phylogenetically disparate species is violently destroy within minutes to a few hours by the so called hyperacute xenograft rejection. Graft rejection in some combinations between pigs and apes begins with antibody recognition by the antigenic targets found in the donor’s blood vessels. Antibodies bound to the antigenic target activate the complement molecules, which in turn lead to the pathogenic process. The xenoreactivity in hyperacute rejection varies a lot from one experiment to another and among different species. There is a little knowledge about the variation in the expression of antigenic targets in potentially donor pigs population. Such quantifications could have many implications for xenotransplantation, because such variability of the antigenic expression would let the identification of species combination with lower reactivity towards each other. This overview posses examination of hyperacute rejection mechanisms observed in the xenogenic experimentation among humans and animals.


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