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Órgano Oficial de la Asociación Mexicana de Hepatología

2013, Number 3

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Ann Hepatol 2013; 12 (3)

Dendritic cells in NASH: Friend or foe?

Handa P, Kowdley KV

Language: English
References: 14
Page: 508-509
PDF size: 65.56 Kb.


Text Extraction

Comment:
Nonalcoholic fatty liver disease (NAFLD) may be the most common chronic liver disease in the world. The spectrum of NAFLD ranges from simple steatosis to nonalcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma. NAFLD is often associated with obesity, insulin resistance and metabolic syndrome.


REFERENCES

  1. Farrell GC, van Rooyen D, Gan L, Chitturi S. NASH is an Inflammatory Disorder: Pathogenic, Prognostic and Therapeutic Implications. Gut Liver 2012; 6: 149-171.

  2. Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications. Cusi K. Gastroenterology 2012; 142: 711-25.

  3. Zhan YT, An W. Roles of liver innate immune cells in nonalcoholic fatty liver disease. World J Gastroenterol 2010; 16: 4652-60.

  4. Tosello-Trampont AC, Landes SG, Nguyen V, Novobrantseva TI, Hahn YS. Kupffer cells trigger nonalcoholic steatohepatitis development in diet-induced mouse model through tumor necrosis factor-á production. J Biol Chem 2012; 287: 40161-72.

  5. Radaeva S, Sun R, Jaruga B, Nguyen VT, Tian Z, Gao B. Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners. Gastroenterology 2006; 130: 435-52.

  6. Henning JR, Graffeo CS, Rehman A, Fallon NC, Zambirinis CP, Ochi A, Barilla R, et al. Dendritic cells limit fibro-inflammatory injury in NASH. Hepatology 2013. Doi: 10.1002/ hep.26267 [Epub ahead of print].

  7. Schmidt SV, Nino-Castro AC, Schultze JL. Regulatory dendritic cells: there is more than just immune activation. Front Immunol 2012; 3: 274.

  8. Liu K, Nussenzweig MC. Origin and development of dendritic cells. Immunol Rev 2010; 234: 45-54.

  9. Hespel C, Moser M. Role of inflammatory dendritic cells in innate and adaptive immunity. Eur J Immunol 2012; 42: 2535-43.

  10. Hebbard L, George J. Animal models of nonalcoholic fatty liver disease. Nat Rev Gastroenterol Hepatol 2011; 8: 35-44.

  11. Hume DA. Macrophages as APC and the dendritic cell myth. J Immunol 2008; 181: 5829-35.

  12. Bennett CL, Clausen BE. DC ablation in mice: promises, pitfalls, and challenges. Trends Immunol 2007; 28: 525-31.

  13. van Blijswijk J, Schraml BU, Reis e Sousa C. Advantages and limitations of mouse models to deplete dendritic cells. Eur J Immunol 2013; 43: 22-6.

  14. Tittel AP, Heuser C, Ohliger C, Llanto C, Yona S, Hämmerling GJ, Engel DR, et al. Functionally relevant neutrophilia in CD11c diphtheria toxin receptor transgenic mice. Nat Methods 2012; 9: 385-90.




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