2015, Number 2
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Gac Med Mex 2015; 151 (2)
Male aged 31 years with polyneuropathy, prostration, and hypogonadism
del Río PAF, Reza AAA, Gómez PFJ
Language: Spanish
References: 10
Page: 256-259
PDF size: 144.87 Kb.
ABSTRACT
We present the case of a 31 year-old male patient, who presented polyneuropathy, symmetrical, ascending, and progressive, that
led to prostration of eight months duration, accompanied by hypogonadism, hypothyroidism, hyperprolactinemia, and the
presence of multiple erythematous nodules on the skin. The MRI showed hypointense lesions in the vertebrae T-6 and L-4
with sclerotic appearance. The bone marrow biopsy reported the presence of 12% plasma cells with λ restriction, supporting
monoclonal gammopathy (plasmocytoma).
REFERENCES
Dispenzieri A. POEMS syndrome: update on diagnosis, risk-stratification, and management. Am J Hematol. 2012;87:805-14.
Dispenzieri A, Kyle R, Lacy M, et al. POEMS syndrome: definitions and long-term outcomes. Blood. 2003;101:2496-506.
Gherardi RK, Belec L, Soubrier M, et al. Overproduction of proinflammatory cytokines imbalanced by their antagonists in POEMS syndrome. Blood. 1996;87:1458-65.
D’Souza A, Hayman SR, Buadi F, et al. The utility of plasma vascular endothelial growth factor levels in the diagnosis and follow-up of patients with POEMS Syndrome. Blood. 2011;118:4663-5.
Gandhi G, Basu R, Dispenzieri A, Basu A, Montori V, Brennan M. Endocrinopathy in POEMS syndrome: The Mayo Clinic Experience. Mayo Clin Proc. 2007;82(7):836-42.
Humeniuk M, Gertz M, Lacy M, et al. Outcomes of patients with POEMS syndrome treated initially with radiation. Blood. 2013;122:68-73.
Dispenzieri A. How I treat POEMS syndrome. Blood. 2012;119:5650-8.
D´Souza A, Lacy M, Gertz M, et al. Long-term outcomes after autologous stem cell transplantation for patients with POEMS syndrome (osteosclerotic myeloma): a single-center experience. Blood. 2012;120:56-62.
Li J, Zhang W, Jiao L, et al. Combination of melphalan and dexamethasone for patients with newly diagnosed POEMS syndrome. Blood. 2011;117:6445-9.
Dispenzieri A. POEMS syndrome. Blood Rev. 2007;21:285-99.