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2015, Number 2

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Rev Cub de Reu 2015; 17 (2)

Biological and oxidative stress markers in the evolution of patients with rheumatoid arthritis

Sansaricq CI, Céspedes MEM, Molinet FEJ, Peña SM

Language: Spanish
References: 35
Page: 132-138
PDF size: 390.51 Kb.


ABSTRACT

Introduction: rheumatoid arthritis is an autoimmune and inflammatory disease of unknown cause. In the Rheumatology services, the evolution of the patients is valued by means of erythrocyte sedimentation rate and C-reactive protein. It has been suggested that the oxidative stress contributes to the joint tissue damage.
Objective: to analyze differential leukocyte count and oxidative damage in patients with Rheumatoid Arthritis in crisis and remission periods.
Methods: prospective study in which global and differential leukocytes count, thiobarbituric acid reactive substances as a marker of lipid peroxidation, the superoxide dismutase, as well as the catalase activities were measured in 23 patients during their crisis and remission periods. C-reactive protein, erythrocyte sedimentation rate and rheumatoid factor were measured, too.
Results: rheumatoid factor was over 15 U/ml in the 82.61 % of the patients. A minor neutrophils count was observed in the remission period in relation to the active period of the disease (5.03 ± 1.51 vs. 4.21 ± 1.24 ×10-9/L, p=0.003), as well as the global leukocytes count, the erythrocyte sedimentation rate and the C-reactive protein. It was verified that the catalase activity decreased in remission state in relation to the crisis period (445.31 ± 281.87 vs. 1046.08 ± 659.77 U×L-1min-1).
Conclusions: in the evolution of the rheumatoid arthritis, the neutrophils count is in correspondence with the inflammatory state of the patients. Catalase activity is consistent with the regulation of this enzyme to protect against oxidative stress.


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