Rios GBBE, Saldarriaga RLM, Valentim SVC, Ponce Leon PCFB, Fragoso PPJ, Serra WJ, de Carvalho FC, Leitão AMN

Language: Portugués
References: 22
Page: 120-125
PDF size: 354.84 Kb.

ABSTRACT

Introduction: immunoglobulin A is responsible for protecting the infections of the respiratory and gastrointestinal tracts, and selective immunoglobulin A deficiency is the most common primary humoral immunodeficiency. It is speculated that their occurrence may predispose to the development of systemic lupus erythematous.
Objectives: to study the prevalence of selective immunoglobulin A deficiency in patients with juvenile systemic lupus erythematosus and compared between groups of patients with and without selective immunoglobulin A deficiency, age and clinical manifestations at diagnosis of juvenile systemic lupus erythematosus and the index of disease activity at the time of analysis IgA levels, family history of rheumatic diseases, autoimmune and/or congenital immunodeficiency’s.
Patients and methods: we reviewed the medical records of 63 patients diagnosed with lupus according to the criteria of the American College of Rheumatology. Immunoglobulin A plasma levels of these patients were measured by nephelometry and were considered low when less than 70 mg/dL. Demographic data and clinical and laboratory profile, and family history were obtained by review of medical records.
Results: selective immunoglobulin A deficiency was detected in 3 of 63 patients (4.8 %). The clinical and laboratory profile of selective immunoglobulin A deficiency group was not significantly different from the group without selective immunoglobulin A deficiency and it was not observed higher incidence of infections in this group of patients.
Conclusion: we observed a higher prevalence of selective immunoglobulin A deficiency in patients with juvenile-onset systemic lupus erythematosus compared with the general population, with no significant differences between the clinical and laboratory profile of patients with and without selective immunoglobulin A deficiency.

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