2014, Number 2
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Ann Hepatol 2014; 13 (2)
SVR24 rates in patients with HCV genotype 5 and 6 infection treated with peginterferon alfa-2a (40KD) plus ribavirin: results from the real world PROPHESYS study
D’heygere F, George C, Habersetzer F, Tripathi D, Pan CQ, Giron JA, Schmitz M, Tatsch F
Language: English
References: 5
Page: 303-304
PDF size: 66.14 Kb.
Text Extraction
Infection with hepatitis C virus (HCV) genotype
(G)5 or G6 is relatively uncommon worldwide, with
data on the efficacy of peginterferon/ribavirin (PegIFN/
RBV) treatment limited, and sometimes contradictory
compared with other HCV genotypes. G5
is predominantly found in South Africa, with local
clusters reported in France, Spain, Syria, Belgium
and Canada, while G6 has been reported in Asian
countries and patients of Asian origin in the US
and Canada.4 Here, we report data from the 25
G5 and G6 patients from the “real world” PROPHESYS
study5 receiving PegIFN alfa-2a (40KD)
(PEGASYS
®, Roche, Basel, Switzerland) plus RBV.
REFERENCES
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Lam KD, Trinh HN, Do ST, Nguyen TT, Garcia RT, Nguyen T, Phan QQ, et al. Randomized controlled trial of pegylated interferon-alfa 2a and ribavirin in treatment-naive chronic hepatitis C genotype 6. Hepatology 2010; 52: 1573-80.
Mauss S, Berger F, Vogel M, Pfeiffer-Vornkahl H, Alshuth U, Rockstroh JK, Niederau C, et al. Treatment results of chronic hepatitis C genotype 5 and 6 infections in Germany. Z Gastroenterol 2012; 50: 441-4.
Antaki N, Craxi A, Kamal S, Moucari R, Van der Merwe S, Haffar S, Gadano A, et al. The neglected hepatitis C virus genotypes 4, 5 and 6: an international consensus report. Liver Int 2010; 30: 342-55.
Marcellin P, Cheinquer H, Curescu M, Dusheiko G, Ferenci P, Horban A, Jensen D, et al. High sustained virologic response rates in rapid virologic response patients in the large real-world PROPHESYS cohort confirm results from randomized clinical trials. Hepatology 2012; 56: 2039-50.