Guevara-López U

Language: Spanish
References: 0
Page: 33-56
PDF size: 218.28 Kb.

ABSTRACT

Modifications in the alpha-methyl group of indole-3-acetic acid and in the carboxyl group, as well as substitution of heterocyclic rings in the fundamental indole framework of indometacin led to the synthesis of a new nonsteroidal anti-inflammatory drug,acemetacin(C₂₁H₁₈ClNO₆). Its physicochemical properties, such as coalition range, molecular weight, dissociation index, solubility and stability, turn it into an NSAID with clinical properties that set it apart from other drugs in its class. In spite of its activity as a cyclooxygenase-1 (COX-1)inhibitor, it has greater activity as a COX-2 inhibitor, with a considerable anti-inflammatory and analgesic effect that make it highly effective in various rheumatologic conditions and other inflammatory diseases. This review summarizes the major pharmacological and clinical features of this analgesic drug, so the clinician may take it into account as an alternative drug for the relief of acute and chronic pain.