Poucel-Sánchez-Medal F, Cárdenas SCM, Villaseñor VE, Gutiérrez SJE

Language: Spanish
References: 17
Page: 101-105
PDF size: 293.68 Kb.

ABSTRACT

Silicone breast implants have been in use for breast reconstruction and breast augmentation for a long time. Few implantable medical devices have been studied for their safety more extensively than silicone gel-filled breast implants. In the late 80’s anecdotal reports describing a possible association between silicone gel-filled breast implants, and autoimmune diseases were accumulated. Since then, long-term safety data has been important in the evaluation of possible adverse health outcomes related to breast implants. In this article the authors review the available literature on the relationship between the use of silicone gel-filled breast implants and connective tissue or autoimmune diseases, emphasizing the most important epidemiologic studies and meta-analyses. Large-scale studies to date have failed to find any credible association between silicone breast implants and either well-defined connective tissue diseases or atypical connective tissue diseases.

REFERENCES

1. Janowsky EC, Kupper LK, Hulke BS. Meta-analyses of the relation between silicone breast implants and the risk of connective-tissue diseases. N Engl J Med. 2000; 342: 781-790.

2. Bar-Meir E, Eherenfeld M, Shoenfeld Y. Silicone gel breast implants and connective tissue disease-a comprehensive review. Autoimmunity. 2003; 36 (4): 193-197.

3. McLaughlin JK, Lipworth L, Murphy DK, Walker PS. The safety of silicone gel-filled breast implants-a review of the epidemiologic evidence. Ann Plast Surg. 2007; 59: 569-580.

4. Spiera H. Scleroderma after silicon augmentation mammoplasty. JAMA. 1988; 260: 236-238.

5. Gabriel SE, O’Fallon WM, Kurland LT, Beard CM et al. Risk of connective-tissue diseases and other disorders after breast implantation. N Engl J Med. 1994; 330: 1697-1702.

6. Sánchez-Guerrero J, Colditz G, Karlson EW, Hunter DJ et al. Silicone breast implants and the risk of connective-tissue diseases and symptoms. N Engl J Med. 1995; 332 (25): 1666-1670.

7. Gott DM, Tinkler JJB. Silicone implants and connective tissue disease. Evaluation of evidence for an association between the implantation of silicones and connective tissue disease. London, UK: Medical Devices Agency; 1994, pp. 34-39.

8. Hennekens CH, Lee IM, Cook NR, Hebert PR et al. Self-reported breast implants and connective-tissue disease in female health professionals. A retrospective cohort study. JAMA. 1996; 275: 616-621.

9. Perkins LL, Clark BD, Klein PJ, Cook RR. A meta-analysis of breast implants and connective tissue disease. Ann Plast Surg. 1995; 35: 561-570.

10. Wong O. A critical assessment of the relationship between silicone breast implants and connective tissue diseases. Regul Toxicol Pharmacol. 1996; 23: 74-85.

11. Hochberg MC, Perlmutter DL. The association of augmentation mammoplasty with connective tissue disease, including systematic sclerosis (scleroderma): a meta-analysis. Curr Top Microbiol Immunol. 1996; 210: 411-417.

12. Breiting VB, Hölmich LR, Brandt B, Fryzek JP et al. Long-term health status of Danish women with silicone breast implants. Plast Reconstr Surg. 2004; 114: 217-226.

13. Brinton LA, Buckley LM, Dvorkina O et al. Risk of connective tissue disorders among breast implant patients. Am J Epidemiol. 2004; 160: 619-627.

14. Lee IM, Cook NR, Shadick NA, Pereira E, Buring JE. Prospective cohort study of breast implants and the risk of connective-tissue diseases. Int J Epidemiol. 2011; 40: 230-238.

15. Rosenkrantz-Hölmich LR, Lipworth L, McLaughlin JK, Friis S. Breast implant rupture and connective tissue disease: a review of the literature. P Reconstr Surg. 2007; 120 (1): 62S-69S.

16. Lipworth L, Tarone RE, McLaughlin JF. Silicone breast implants and connective tissue disease. An updated review of the epidemiologic evidence. Ann Plast Surg. 2004; 52 (6): 598-601.

17. Fryzek JP et al. A nationwide study of connective tissue disease and other rheumatic conditions among Danish women with long-term cosmetic breast implantation. Ann Epidemiol. 2007; 17: 374-379.