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2014, Number 4

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Rev Mex Cir Pediatr 2014; 18 (4)

Prognostic Factors Related With Mortality In Children With Biliary Atresia

Monroy-Teniza ZA, Flores-Calderón J, Villasis-Keever MA, Ortiz-Galvan R, Oliver-García EF, Jean-Aureliusa P, Ayala-Hernández VI

Language: Spanish
References: 15
Page: 183-192
PDF size: 393.32 Kb.


ABSTRACT

Background. Biliary atresia (BA) is a destructive process, idiophatic and inflamatory, that affects the bile ducts intra and extrahepatic, resulting in fibrosis, obliteration of biliary tract and biliary cirrhosis. It has high rates of mortality. It is the principal cause of liver transplantation in pediatrics.
Methods. Observational, longitudinal, analytic and retrospective study; retrospective cohort. Included newborns and infants with BA of 2008 to 2012, excluded patients with acute liver failure or secondary cholestasis to other causes.
Results. Included 66 patients with BA, Kasai was performed in 47, and they had decreased bilirubin levels. Also, in the other group they had lower levels of serum albumin and greater extension of PPT and INR. The survival in the whole group was 5.6 years; for transplant patients, of 1.9 years. The rate of patients with Kasai that died, was lower than those that lived (36.4% vs 78.2%).
Conclusions. The most important factor related with the survival of these patients was to perform the Kasai surgery. The early acknowledgement of this illness, and the timely surgical management, decreases the mortality and improves their quality of life.


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