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2007, Number 4

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Dermatología Cosmética, Médica y Quirúrgica 2007; 5 (4)

Effectiveness and Safety of Sunflower Oleodistillate in Children with Mild Atopic Dermatitis

Guevara GE, Ferrusco OMR, Briseño RG, García VA, Hernández AMS, Hernández TM, Romo SC, Villanueva QDG

Language: Spanish
References: 18
Page: 199-204
PDF size: 324.64 Kb.


ABSTRACT

Background: The atopic dermatitis (AD) is characterized by a decrease of the corneum stratum’s capacity to accumulate water, decreased lipid production and alteration in the content of greasy acids. The sunflower oleodistillated is an emollient agent that restores the cutaneous physiologic characteristics. However, it has not been proved in pediatric patients.
Material and Methods: We conducted a clinical open essay, phase IV, that last 8 weeks, in pediatric patients with mild atopic dermatitis to determinate the effectiveness and safety of the sunflower oleodistillate. Evaluations were realized in the 4 and 8 week of the study, the severity of the illness was determined by the Scoring Atopic Dermatitis (SCORAD), the quality of life with the Infants’ Dermatitis Quality of Life Index (IDQLI), for safety issue the patients were interrogated about adverse side effects.
Results: 52 patients were included. The SCORAD at the beginning was 18.5 ± 4.6 vs. 2.8 ± 5.3 at the end (p = 0.001), the basal score of pruritus was 3.3 ± 2.4, by the 8 week was 0.3 ± 1.0 (p = 0.001). The basal IDQLI was 8.4 ± 4.9 and at the end 1.2 ± 2.8 (p = 0.001). The adverse effects were principally pruritus (4 week, 15% and 8 week, 9.6%) and xerosis (4 week, 13.4% and 8 week, 7.6%).
Conclusions: The use of sunflower oleodistillated in patients with mild atopic dermatitis was effective, since it decreased the severity of the illness and improved the quality of life. Its adverse effects were in the application site and self limited.


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