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2014, Number 1

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Cir Plast 2014; 24 (1)

Importance of the ischemia-reperfusion injury in plastic surgery

Ramos-Gallardo G, Miranda AA

Language: Spanish
References: 19
Page: 57-60
PDF size: 185.83 Kb.


ABSTRACT

Ischemia-reperfusion injury is an inevitable process in plastic surgery. After a prolonged ischemia, adenosine triphosphate is reduced and intracellular sodium and calcium increase. When reperfusion occurs, reactive oxygen increases in the mitochondria and a series of events begins that cause initiate tissue injury. Reperfusion causes even more tissue damage than ischemia. Numerous medications, substances and methods have been tested in order to reduce ischemia and reperfusion injury. We can divide the treatment in two parts: pharmacological and non-pharmacological. In the pharmacological treatment, statins (3 hydroxy 3 methylglutaryl coenzyme A reductase inhibitors) as cholesterol reducing agents have shown therapeutic effect on ischemia reperfusion injury in many different organs. As a non-pharmacological treatment, preconditioning consists of a brief alternating episode of ischemia and reperfusion, which triggers an adaptive mechanism, that protects tissues against injury from a subsequent sustained ischemia and reperfusion. This review discusses the effect and treatment of ischemia-reperfusion applied to plastic surgery.


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