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2010, Number 4

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Dermatología Cosmética, Médica y Quirúrgica 2010; 8 (4)

Antioxidants in Dermatology

Castellanos RGI, Alcalá PD

Language: Spanish
References: 31
Page: 272-277
PDF size: 419.70 Kb.


ABSTRACT

The skin is the most directly exposed organ to oxidative damage due to free radicals (FR). Currently there are clinical trials that provide evidence of the benefit of antioxidants (AOs) when applied topically. As a result, the pharmaceutical industry has developed multiple products containing them, mainly as an adjunct therapy against skin aging.
FR are highly reactive molecules capable of modifying the cells in the environment, in particular reactive oxigen species (ROS) can cause keratinocyte apoptosis by way of activation of several intracellular signaling pathways, including caspase 3, cytochrome C, and activation of MAPKs (mitogen-activated protein kinases). Ultraviolet radiation may induce FR formation with subsequent dermo-epidermal damage.
Antioxidants (AOs) are molecules capable of neutralizing FR. The skin has a complex and specialized system of AOs, including superoxide dismutase (SOD), glutathione, ubiquinone, and vitamins C and E. Experimental studies have found antiproliferative activity/anticarcinogenic, photoprotective and anti-aging effect when used topically. The concentration of AOs and the vehicle are important factors in their effectiveness.


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