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2010, Number 1

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Dermatología Cosmética, Médica y Quirúrgica 2010; 8 (1)

Lupus erythematosus profundus: Literature review

Lammoglia-Ordiales L, Kresch-Tronik N, Arenas-Guzmán R, Vega-Memije E

Language: Spanish
References: 40
Page: 33-38
PDF size: 139.08 Kb.


ABSTRACT

Lupus erythematosus profundus (LEP) is a variant of lupus erythematosus cutaneous (LEC) that affects subcutaneous tissue. LEP occurs in 1% to 3% of patients with LEC, and it could be a single manifestation of the disease or it can be associated to DLE or systemic lupus (SLE).
Lupus panniculitis has a female preponderance, and the age range from 30 to 60 years of age. It is suggested that the pathogenesis is a T-lymphocyte autoimmune mediated response. LEP presents as tender deep subcutaneous nodules with predilection for the face, scalp, arms, shoulders, thighs and buttocks. Remision leaves depressed areas. The histopathologic features are usually lobular or mixed panniculits with lymphocytes and plasma cell rich infiltrate. Other common features are lymphoid follicules, hyaline fat necrosis and interface dermatitis. LEP often responds to systemic steroids, thalidomide, antimalarials, dapsone, and in resistant cases other immunosupresants agents. LEP can evolve to LES in 10% to 36%, and usually has a better pregnosis.


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