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2011, Number 4

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Dermatología Cosmética, Médica y Quirúrgica 2011; 9 (4)

Necrobiosis lipoídica. A review

Ochoa SEP, Vega MME, Manzanares N, Arenas R

Language: Spanish
References: 48
Page: 306-313
PDF size: 335.55 Kb.


ABSTRACT

Necrobiosis lipoídica is a chronic granulomatous disease of unknown etiology, usually associated with systemic diseases as diabetes mellitus type 2, lupus erythematosus, and rheumatoid arthritis. It affects the anterior aspect of both legs (85%) and is characterized by red or yellow-brown annular plaques with sclerotic areas. It can be associated with impaired tissue perfusion, collagen fibers abnormalities, alteration on neutrophils, or with infectious agents. Palisading granulomas are characteristic, but pseudotuberculoid granulomas can also be found. Several treatments have been described, such as topical corticosteroids and intralesional monoclonal antibodies.


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