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2011, Number 4

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Dermatología Cosmética, Médica y Quirúrgica 2011; 9 (4)

Thalidomide: From darkness to brightness

Mancheno VA, Rosas MA, Sánchez AK, Ochoa SP, Zepeda LP, Arrazola GJ, Hajar ST, Isunza RA, Rodríguez CAA, Arenas R

Language: Spanish
References: 104
Page: 298-305
PDF size: 217.30 Kb.


ABSTRACT

After the well known thalidomide tragedy that caused severe birth defects in the late fifties and early sixties, this drug has been successfully reborn. Currently, physicians recognize its usefulness for treating several diseases, despite the fact that the Food and Drug Administration (FDA) has only approved its use for erythema nodosum leprosum and multiple myeloma. Thalidomide has several mechanisms of action, and among them, its anti-inflammatory, immunomodulator and anti-angiogenic effects have been extremely useful in dermatology. Therapeutic results have been promising in most of the cases. The best results have been reported in actinic prurigo, erythema nodosum leprosum, aftous stomatitis, Behçet’s disease, erythematous lupus, and nodular prurigo. Nonetheless, its safety is still a source of great concern and controversy in the medical literature.


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