2004, Number 1
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Gac Med Mex 2004; 140 (1)
Vasopressin Use in Shock.
Carrillo-Esper R, González-Salazar JA, Calvo-Carrillo B
Language: Spanish
References: 68
Page: 71-76
PDF size: 460.86 Kb.
ABSTRACT
Arginine-vasopresin (VP), also known as the antidiuretic
hormone, is essential for water homeostasis. Its synthesis
and liberation depends on regulation of osmotic,
hypovolemic, hormonal, and nonosmotic stimuli. It has
been demonstrated that it is key for maintenance of
cardiovascular homeostasis through vasomotor regulation,
the determinant of systemic vascular resistance and mean
arterial pressure, a process acting through V1 receptors.
Shock state with refractary vasodilation seen in sepsis,
systemic inflamatory response, hypovolemia, cardiac arrest,
polytrauma, etc., is characterized by an initial phase of
liberation and increased levels of VP followed by a second
phase caracterized by inappropirately low levels of this
hormone that are associated with refractariness to
management with volume, inotropics, and vasopressors. It
has been demonstrated in clinical and experimental studies
that exogenous VP treatment under this condition increases
systemic vascular resistance, perfusion pressure, and oxygen
supply to peripheral tissues, which makes it possible to
decrease and to suspend vasopressors and also to increase
survival.
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