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2011, Number 4

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Dermatología Cosmética, Médica y Quirúrgica 2011; 9 (4)

Correlation between clinical severity, TNF-α, and insulin-resistance in psoriasis

Ríos YJM, Adames MM, Yuil RE, Guevara Y

Language: Spanish
References: 37
Page: 255-262
PDF size: 156.60 Kb.


ABSTRACT

Background: Though the most visible component of psoriasis is skin disease, recent evidence suggests that psoriasis is a systemic disorder associated with multiple comorbidities, such as insulin resistance syndrome and cardiovascular disease. Tumor necrosis factor alpha (TNF-α), a cytokine associated to psoriasis, induces insulin resistance through various mechanisms, therefore it is probably one of the cytokines responsible for the development of the mentioned comorbidities. The objective of this study is to correlate: clinical severity, blood levels of TNF-α, and the degree of insulin-resistance among psoriatic patients who attended the Dermatology Clinic Complex during December 2010.
Materials and methods: An analytical, correlational, randomized, open trial with 23 patients with psoriasis and 8 patients without psoriasis was performed. Weight, height, body mass index, psoriasis area and severity index, blood glucose levels, blood insulin levels and TNF-α blood levels were determined. Statistical analysis was performed with EpiInfo and EpiDat.
Results: 56.52% of the psoriasis patients were female, 52.17% were obese, 65.22% had mild disease, 17.39% were insulin-resistant, and all had blood TNF-α concentrations below 31.25 pg/ml.
Conclusion: There was no correlation between disease severity and the degree of insulin-resistance, blood glucose levels, nor blood insulin levels among studied patients. There was no correlation between the diagnosis of psoriasis and the presence of insulin resistance, nor TNF-α blood levels above 31.25 pg/ml.


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