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2011, Number 4

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Dermatología Cosmética, Médica y Quirúrgica 2011; 9 (4)

Erythroderma, as a drug reaction

Aldama A, Rivelli V, Martínez L, Perin D, Gugliermone C

Language: Spanish
References: 15
Page: 251-254
PDF size: 136.58 Kb.


ABSTRACT

Background: Erythroderma is a syndrome characterized by erythema and scaling, affecting at least 90% of the body surface. It has numerous causes, being drug reactions one of the most important.
Objectives: To report the data concerning erythroderma caused by drugs in the Dermatology Department at the National Hospital of Paraguay from 1991 to 2011.
Material and methods: Observational and retrospective study. All the patients with erythroderma attributed to oral drugs were included. We excluded cases related to topical medications.
Results: We included 42 cases of drug-induced erythroderma, 22 female and 20 male, most frequently observed in the first and last years of life. Anticonvulsants were responsible for 50% of cases, and among these, carbamazepine was the most common. The diagnosis was clinical and, in some cases, had a pathological report. The most common CBC alterations were eosinophilia and leukocytosis. The treatment consisted in removing the drug, and 16 also received prednisone. The outcome was favourable in all the cases except one who died due to its primary disease which treatment included the drug.
Conclusion: Drugs are the second leading cause of erythroderma, and the evolution once the cause is identified, in general, is better than the other causes.


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