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Anales de Otorrinolaringología Mexicana

2015, Number 1

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Otorrinolaringología 2015; 60 (1)

Comparison of effectiveness of dexamethasone vs diphenidol to reduce postoperative nausea and vomiting in patients undergoing tympanoplasty or mastoidectomy

Guerra-Gómez CA, Gil-Ascencio M, Loretto-Guerra CI, Morgado-Pérez J

Language: Spanish
References: 19
Page: 1-5
PDF size: 330.02 Kb.


ABSTRACT

Background: Postoperative nausea and vomiting are the most common postoperative complications in otologic surgery. The antiemetic proper ties of dexamethasone and diphenidol have been described; however, diphenidol is the drug currently used as first choice.
Objective: To compare the efficacy of dexamethasone and diphenidol in adult patients undergoing tympanoplasty and/or mastoidectomy in preventing postoperative nausea and vomiting.
Material and method: A randomized open clinical trial was done with 78 patients divided into two groups randomly. Group A received diphenidol 40 mg IV and group B was given dexamethasone 8 mg IV at the end of the surgical procedure; the survey of Bellville for nausea and vomiting was used in the immediate postoperative period and 8 hours later.
Results: Seventy-eight patients were enrolled (39 per group); 16 patients (41%) in group A reported nausea (92.3%) versus 36 in group B (p=0.04). Two patients (5.1%) in group A had at least one episode of vomiting versus 12 (30.8%) in group B (p=0.003).
Conclusions: Dexamethasone is more effective than IV diphenidol to reduce nausea and vomiting in adult patients undergoing mastoidectomy and/or tympanoplasty.


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