Bravata-Alcántara JC, Chávez-Ocaña S, Sierra-Martínez M

Language: Spanish
References: 17
Page: 182-187
PDF size: 292.83 Kb.

ABSTRACT

In acute lymphoblastic leukemia (ALL), various types of chromosomal alterations with prognostic value are reported well known, these changes allow us to evaluate the response to treatment and survival. Cytogenomics currently allows to know the behavior of leukemias using high-density microarrays, as it has been observed that higher detection. With microarrays can detect losses that are closely related genes as clinically; CDKN2A/B, ETV6, PAX5 and IKZF1, which are associated with the expression and regulation of genes that contribute to neoplastic transformation in hematopoiesis and are located in cells of type B. With these technological advances in microarray platforms, we have allowed more knowledge to understand the processes of leukemogenesis, for therapeutic targets, and deliver personalized medicine. But we still need to understand mechanisms that allow us to identify why there are differences in the origin and frequency of chromosome abnormalities among children and adults.

REFERENCES

1. Hoelzer D, Thiel E, Loffler H, Bodenstein H, Plaumann L, Buchner T, Urbanitz D, et al. Intensified therapy in acute lymphoblastic and acute undifferentiated leukemia in adults. Blood 1984; 64(1): 38-47.

2. Del Vecchio L, Di Noto R, Lo Pardo C, Schiavone EM, Vacca C, Ferrara F, Rotoli B. Immunological classification of acute leukemias: comments on the EGIL proposals. Leukemia 1996; 10(11): 1832-3.

3. Mrozek K, Harper DP, Aplan PD. Cytogenetics and molecular genetics of acute lymphoblastic leukemia. Hematology/ oncology Clinics of North America 2009; 23(5): 991-1010.

4. Mullighan CG. The molecular genetic makeup of acute lymphoblastic leukemia. ASH Education Program Book 2012; 2012(1): 389-96.

5. Cook SA, Rosenzweig A. DNA microarrays: implications for cardiovascular medicine. Circ Res 2002; 91(7): 559-64.

6. Aitman TJ. DNA microarrays in medical practice. BMJ 2001; 323(7313): 611-5.

7. Schulze A, Downward J. Navigating gene expression using microarrays—a technology review. Nature cell biology 2001; 3(8): E190-e195.

8. Copland JA, Davies PJ, Shipley GL, Wood CG, Luxon BA, Urban RJ. The use of DNA microarrays to assess clinical samples: the transition from bedside to bench to bedside. Recent progress in hormone research 2003; 58: 25-53.

9. Xu X, Johnson EB, Leverton L, Arthur A, Watson Q, Chang FL, Raca G, Laffin JJ. The advantage of using SNP array in clinical testing for hematological malignancies—a comparative study of three genetic testing methods. Cancer Genetics 2013; 206(9- 10): 317-26.

10. Laskowska J, Szczepanek J, Styczynski J, Tretyn A. Array comparative genomic hybridization in pediatric acute leukemias. Pediatr Hematol Oncol 2013; 30(8): 677-87.

11. Kuiper RP, Schoenmakers EF, van Reijmersdal SV, Hehir- Kwa JY, van Kessel AG, van Leeuwen FN, Hoogerbrugge PM. High-resolution genomic profiling of childhood ALL reveals novel recurrent genetic lesions affecting pathways involved in lymphocyte differentiation and cell cycle progression. Leukemia 2007; 21(6): 1258-66.

12. Medeiros BC. Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia. N Eng J Med 2009; 360(17): 1787. Author reply: 1787-8.

13. Simons A, Stevens-Kroef M, El Idrissi-Zaynoun N, van Gessel S, Weghuis DO, van den Berg E, Waanders E, et al. Microarraybased genomic profiling as a diagnostic tool in acute lymphoblastic leukemia. Genes, Chromosomes Cancer 2011; 50(12): 969-81.

14. Kawamata N, Ogawa S, Seeger K, Kirschner-Schwabe R, Huynh T, Chen J, Megrabian N, et al. Molecular allelokaryotyping of relapsed pediatric acute lymphoblastic leukemia. Int J Oncol 2009; 34(6): 1603-12.

15. Okamoto R, Ogawa S, Nowak D, Kawamata N, Akagi T, Kato M, Sanada M, et al. Genomic profiling of adult acute lymphoblastic leukemia by single nucleotide polymorphism oligonucleotide microarray and comparison to pediatric acute lymphoblastic leukemia. Haematologica 2010; 95(9): 1481-8.

16. Calasanz MJ, Cigudosa JC. Molecular cytogenetics in translational oncology: when chromosomes meet genomics. Clin Transl Oncol 2008; 10(1): 20-9.

17. Yasar D, Karadogan I, Alanoglu G, Akkaya B, Luleci G, Salim O, Timuragaoglu A, et al. Array comparative genomic hybridization analysis of adult acute leukemia patients. Cancer Genet Cytogenet 2010; 197(2): 122-9.