2014, Number 2
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Rev Cubana Farm 2014; 48 (2)
Determination of biflavonoids in different parts of Garcinia bakeriana (Urb) Borhidi
Al-Shaghdari A, Bello AA, Cuesta-Rubio O
Language: Spanish
References: 18
Page: 307-315
PDF size: 227.21 Kb.
ABSTRACT
Introduction: previous studies have revealed genus Garcinia to be a rich source of secondary metabolites, namely xanthones, acylphloroglucinols and bioflavonoids.
However, the chemical composition of Cuban species in this genus is almost unknown.
Objective: to determine the presence of 11 biflavonoids in
Garcinia bakeriana leaves, latex and stem bark.
Methods: leaves, latex and stem bark extracts of
G. bakeriana were compared by using an ultra high performance liquid chromatography method (UPLC) and 11
biflavonoid standards.
Results: biflavonoids GB-1A, GB-2A, GB-2A glycoside, morelloflavone glycoside, 4´´´methoxy- I3,II8-biapigenin, I3,II8-biapigenin, amentoflavone y 4´´´-
methoxyamentoflavone were detected as components in
G. bakeriana leaves and stem bark.
Conclusions: G. Bakeriana species has biflavonoids as components of its leaves and stem bark. The work methodology described in this paper helps to expand the knowledge about the chemical composition of the Cuban flora and may represent a rapid method with low dissolver consumption for the comparative study of poorly
distributed and non abundant Cuban endemic species.
REFERENCES
Waterman PG, Hussain RA. Systematic Significance of Xanthones, Benzophenones and Biflavonoids in Garcinia. Biochemical Systematics and Ecology. 1983;11(1):21-8.
Baliga MS, Bhat HP, Pai RJ, Boloor R, Palatty PL. The chemistry and medicinal uses of the underutilized Indian fruit tree Garcinia indica Choisy (kokum): A review. Food Res Intern. 2011;44(7):1790-9.
Dos Santos MH, Nagem TJ, Lula IS. Complete assignment of the ¹H and ¹³C NMR spectra of the tetraisoprenylated benzophenone 15-epiclusianone. Magnetic Resonance in Chemistry. 2001;39(1):155-9.
Chomnawang M, Surassmo S, Nukoolkarn VS, Gritsanapan W. Effect of Garcinia mangostana on inflammation caused by Propionibacterium acnes. Fitoterapia. 2007;78(1):401-8.
Chen J, Yong L, Yan-Ping S. Determination of flavonoids in the flowers of Paulownia tomentosa by high-performance liquid chromatography. J Analyt Chem. 2009;64(3):282-8.
Carvalho-Silva LB, Oliveira MV, Gontijo VS, Oliveira WF, Derogis P, Stringheta PC, et al. Antioxidant, cytotoxic and antimutagenic activities of 7-epi-clusianone obtained from pericarp of Garcinia brasiliensis. Food Res Intern. 2012;48(1):180-6.
Verdi LG, Pizzolatti MG, Montanher AB. Antibacterial and brine shrimp lethality tests of biflavonoids and derivative of Rheedia gardneriana. Fitoterapia. 2004;75(1):360-3.
Rui-Min H, Yu-Xi T, Yin L, Chang-Hui C, Xi-Cheng A, Jian-Ping Z, et al. Comparison of flavonoids and isoflavonoids as antioxidants. J Agricult Food Chem. 2009;57(9):3780-5.
Jawed AS, Swarnkar G, Sharan K, Chakravarti B, Sharma G, Rawat P, et al. 8,8″-Biapigeninyl stimulates osteoblast functions and inhibits osteoclast and adipocyte functions: Osteoprotective action of 8,8″-biapigeninyl in ovariectomized mice. Art Mol Cel Endocrinol. 2010;323(2):256-66.
Cuesta-Rubio O, Padrón A, Vélez-Castro H, Pizza C, Rastrelli L. Aristophenones A and B A new tautomeric pair of polyisoprenylated benzophenones from Garcinia aristata. J Nat Product. 2001;64:973-5.
Al-Shaghdari A, Bello-Alarcón A, Cuesta-Rubio O, Piccinelli AL, Rastrelli L. Biflavonoids, Main Constituents from Garcinia bakeriana Leaves. Natural Product Communications. 2013;8(9):1237-40.
Douglas AK, Hee-byung C, Chung KS, William JK. The classical drug discovery approach to defining bioactive constituents of botanicals. Fitoterapia. 2011;82(1):71-9.
Gontijo VS, Judice WAS, Codonho B, Pereira IO, Assis DM, Januário JP, et al. Leishmanicidal, antiproteolytic and antioxidant evaluation of natural biflavonoids isolated from Garcinia brasiliensis and their semisynthetic derivatives. Eur J Med Chem. 2012;58:613-23.
Hong-Xi X, Sumaya M, Oluronke T, Song FL. Isolation and characterization of an antibacterial biflavonoid from an African chewing stick Garcinia kola Heckel (Clusiaceae). J Ethnopharmacol. 2013;147(2):497-502.
Bharathi A, Yan-Hong W, Rahul SP, Yatin JS, Troy JS, Ikhlas AK. A rapid method for chemical fingerprint analysis of Hoodia species, related genera, and dietary supplements using UPLC-UV-MS. J Pharmaceut Biomed Anal. 2011;48(3):722-31.
Yan Z, Sheng-Xiong H, Jian-Xin P, Jin-Rong L, Li-Sheng D, Dao-Feng C, et al. Ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometric procedure for qualitative and quantitative analyses of nortriterpenoids and lignans in the genus Schisandra. J Pharmaceut Biomed Anal. 2011;56(5):916-27.
Yuh-Meei L, Flavin MT, Cassidy CS, Aye M, Fa-Chin C. Biflavonoids as a novel antituberculosis agent. Bioorg Med Chem Let. 2001;11(1):2101-4.
Castardo JC, Prudente AS, Ferreira J. Anti-inflamatory effects of hydroalcoholic extract and two biflavonoids from Garcinia garneriana leaves in mouse paw o edema. J Ethnopharmacol. 2008;118(3):405-11.