2014, Number 5
<< Back Next >>
Acta Pediatr Mex 2014; 35 (5)
Experience of ten years of neutropenic enterocolitis in intensive care at Instituto Nacional de Pediatría
Muñoz-Ramírez M, Márquez-González H, Zárate-Castañón P, Márquez-Aguirre MP
Language: Spanish
References: 18
Page: 381-387
PDF size: 541.97 Kb.
ABSTRACT
Neutropenic enterocolitis (NEC) is a disease characterized by an inflammatory
process with damage to the intestinal mucosa and occurs as a
complication of cytotoxic chemotherapy in oncological diseases, and
severe neutropenia secondary to other diseases.
Objective: To describe the population of patients with NEC who are
served in the pediatric intensive care unit at Instituto Nacional de
Pediatría.
Methods: 10-year data of patients registered with a diagnosis of NEC
(1 500 cel/μL less neutropenia, acute abdomen, consistent studies cabinet)
on admission to the intensive therapy that consisted of: age, type
of cancer, organ failure, stage of sepsis, medical treatment and surgical
management. Frequencies and percentages for qualitative; statistical
analysis for measures of dispersion and central tendency were used for
quantitative variables.
Results: Population of 116 patients, 69 (60%) were men. The leukemia
is the most common malignancy in 55%. 35% of patients corresponded
to stage school. Sepsis was the most common presentation. Abdominal
pain symptom most frequently found. 33% died as a result.
Conclusions: The present study is exploratory in nature and compares
the local epidemiology of the Instituto Nacional de Pediatría with UTIP
world.
REFERENCES
Shamberger R, Weinstein HJ, Delorey MJ. The medical and surgical management of typhlitis in children with acute non lymphocytic leukemia. Cancer 1986;57:603-9.
Calderón EC, Cardoso HG, Ruano JM. Enterocolitis neutropénica en niños con cáncer. Act Pediatr Méx 2003;24(2):108-16.
Sundell Nicklas, Boström Håkan, Edenholm Mats, Abrahamsson Jonas. Management of neutropenic enterocolitis in children with cáncer. Acta Pædiatrica 2012;11:308–312.
Durán-Pérez EG, Lujano-Nicolás LA, Ornelas-Escobedo E, Abdo-Francis JM. Enterocolitis neutropénica. Rev Med Hosp Gen Mex 2010;73(3):202-8.
Baniel J, Lombrozo R, Zib Y, Wolloch J. Neutropenic enterocolitis: cas report. Act Chir Scand 1988;154:71-3.
Wade DS, Nava HR, Douglas HO. Neutropenic enterocolitis: clinical diagnosis and treatment. Cancer 1992;69:17-23.
Goldstein Brahm, Giroir Brett, Randolph Adrienne. International pediatric sepsis consensus conference: Definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med 2005;6(1):3-8.
Sloas M, Flum P, Kaste S, Patrick C. Typhlitis in children with cancer: 30 year experience. Clin Infect Dis 1993;17:484-90.
Cook JV. Acute leukemia in children. JAMA 1933;101:432-5.
Prolla JC, Kirsner JB. The gastrointestinal lesions and complications of leukemias. Ann Int Med 1964;61(6):1084-1103.
DosiK GM, Luna M, Valdivieso M, McCredle KB, Gehan EA, Gil-Extremera B. Necrotizing colitis in patients with cancer. Am J Med 1979;67:646-55.
Fajardo-Gutierrez A, Rendon-Macías ME, Mejía-Aranguré JM. Epidemiología del cáncer en niños mexicanos. Rev Med Inst Mex Seguro Soc 2011;49(1):s43-s70.
Soriano RJ, González CE, Vicuña GR, Jastrow BL, Guevara B, Mondragón GA. Enterocolitis neutropénica estudio de 16 casos en pacientes con leucemia en un periodo de 12 años. Rev Med Hosp Gen 1996;59:15-18.
Baerg J, Murphy J, Anderson R, Fergall MJ. Neutropenic enteropathy: a 10 year review. J Pediatr Surg. 1999;34(7):1068-1071.
Starnes HF, Moore FD, Mentzer S. Abdominal pain in neutropenic cancer patients. Cancer 1986;57:616-621.
Wade DS, Nava HR, Douglas HO. Neutropenic enterocolitis, clinical diagnosis and treatment. Cancer 1992:69:17-23.
Slavin RE, Dias MA, Saral R. Cytosine arabinoside induced gastrointestinal toxic alterations in sequential chemotherapeutic protocols: a clinical pathologic study of 33 patients. Cancer 1978;42:1747-59.
Kuffer F, Fortner J, Murphy L. Surgical complications in children undergoing cancer therapy. Ann Surgery 1968;167:215-219.