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2013, Number 4

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Dermatología Cosmética, Médica y Quirúrgica 2013; 11 (4)

Vitamin D in dermatology: A literature review

García GA, Sánchez AK, Domínguez CJ

Language: Spanish
References: 98
Page: 270-276
PDF size: 169.48 Kb.


ABSTRACT

Vitamin D is a fat-soluble hormone whose autocrine signals inhibit cellular progression, differentiation and apoptosis via receptors in multiple cell lines. Plasma levels under 20 ng/mL are considered deficient, and recent studies have linked this deficiency with an increased incidence of asthma and allergies.
Its function in preserving the epidermal barrier, and modulating antimicrobial peptides and the immune response impacts the pathogenesis of atopic dermatitis, and has been related to the development of diseases such as psoriasis and vitiligo. Vitamin D induces production of folliculogenesis-regulating genes, thus promoting regeneration and follicle maturation. Its inhibitory role in the proliferation and promotion of cell differentiation has been studied in melanoma and nonmelanoma skin cancers.


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