2014, Number 4
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Rev Hematol Mex 2014; 15 (4)
ALK positive spine extranodal anaplastic lymphoma
Corona-Hernández MA, Hernández-Rodríguez S, Rivera-Trujillo A
Language: Spanish
References: 19
Page: 190-195
PDF size: 438.04 Kb.
ABSTRACT
The non-Hodgkin’s anaplastic large T cells is a rare, aggressive with
advanced disease entity. Extranodal involvement is seen in more than
half of the cases; it is more frequent in bone and soft tissue. The non-
Hodgkin’s lymphoma presented as spinal cord compression is rare
and occurs in less than 5% of cases. In Mexico there are no previous
reports of clinical cases of patients with anaplastic lymphoma with
primary localization in spinal cord. We report the case of a patient
with clinical manifestations of motor and sensory deficits in the lower
extremities without systemic symptoms. MRI of thoracic spine showed
spinal additional tumor in T3-T5 with spinal cord compression. The
patient tumor resection was performed and histopathologic result was
anaplastic large cell lymphoma in soft tissue spine ALK +, positive CD30,
EMA, CD45, CD68 and vimentin. Patient received local radiotherapy
and chemotherapy with MACOP scheme B. The post-treatment PET/CT
showed no tumor activity. Clinically the patient is in complete remission
with relieve of neurological manifestations.
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