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Colegio de Medicina Interna de México.

2014, Number 6

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Med Int Mex 2014; 30 (6)

Ferritin levels in relation to ejection fraction left ventricular postacute myocardial infarction. A pilot study in Mexican population

Flores-López EN, Vidal-Flores D, García-Padilla E, Lasses y Ojeda LA, Aguilar-De la Torre DL, Ramos-Peñafiel CO, Salcedo-Roldán M, Arias-Ledesma V

Language: Spanish
References: 55
Page: 667-674
PDF size: 544.20 Kb.


ABSTRACT

Background: It has been found that despite the many cytoprotective functions, ferritin is also a source of active iron catalyst, causing oxidative damage with superoxide radicals generated by cell stimulation, which may cause the release of iron from ferritin. Many studies have been commissioned to monitor the association between levels of this molecule and the relationship with ischaemic heart disease.
Objective: To determine if there is a relation between levels of ferritin determined at entering and seven days after the event and the postinfarction left ventricular ejection fraction.
Material and method: An observational, cross-sectional study was done at General Hospital of Cuautitlan, Estado de Mexico, from June 20, 2013 to January 2014, in which were included patients attending to Emergency room with acute coronary syndrome type myocardial acute infarction with elevation of ST segment, during the first hours of the beginning of th event. It was performed the enzymatic determination of total and fraction MB creatinin-phosphokinase, lactic deshidrogenase and transaminases at entering, besides determining levels of ferritin, glucose, uric acid, cholesterol and triglycerides and doing a complete hematic biometry. Also, the diagnosis of myocardial acute infarction with elevation of segment ST was established with the criteria of the third universal definition of infarction and following the guides ACC/AHA.
Results: The mean level of the first and second determination of ferritin was of 448.2 and 516 ng/dL, respectively; the mean left ventricular ejection fraction was of 42%.
Conclusions: This study is consistent with many of the articles that refer that there is no relationship between left ventricular ejection fraction and ferritin levels in acute myocardial infarction.


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