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ISSN 0185-3252 (Print)
Revista de la Asociación Médica del Centro Médico ABC

2014, Number 4

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An Med Asoc Med Hosp ABC 2014; 59 (4)

MicroRNAs in breast cancer

Ochoa ARE, González BP, González LLE, González CSA, Fuentes CRE, Barragán PDL

Language: Spanish
References: 11
Page: 267-270
PDF size: 206.79 Kb.


ABSTRACT

Currently the scientific community is researching for breast cancer biomarkers. In genetics, miRNAs have been studied. MiRNAs are non-codifying endogenous nucleotides that exist throughout the DNA code. MicroRNAs have been identified with oncogene, tumor suppressor gene, and oncogene with tumor suppressor gene functions. The relevance of this is that miRNAs can be used as biomarkers for breast and other cancers. Another use for miRNAs is their prognosis at the evaluation of treatment response and their utility in selecting the ideal therapy for each patient. Because of this, it is important to analyze the miRNAs in the patient’s serum, plasma or other biofluids to determine the possible therapies for each miRNA, whether an oncogene, tumor suppressor gene or both. According to Shen Lei and his team, about 72.8% of breast cancer exhibits an abnormality in the number of miRNAs genes. With this background, the objective of this document is to provide clinicians with a brief introduction to the molecular biology of breast cancer through the most studied miRNAs.


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