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ISSN 0185-3252 (Print)
Revista de la Asociación Médica del Centro Médico ABC

2014, Number 4

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An Med Asoc Med Hosp ABC 2014; 59 (4)

Description and preliminary analysis of intra-arterial treatment for intraocular retinoblastoma in México

Gilberto Gómez GG, Bernal MMA, Higuera CJ, Bosch CV, Isaac OG, Leal LC

Language: Spanish
References: 18
Page: 252-256
PDF size: 231.58 Kb.


ABSTRACT

Introduction: Retinoblastoma is the most frequent ocular malignant tumor of infancy and is potentially curable. The treatment is aimed at saving the patient’s life, but also at the preservation of the organ and visual function. A new eye-preserving intra-arterial chemotherapy technique by selective catheterization of the ophthalmic artery was recently implemented in our country. We describe the technique and the preliminary results in our patients. Method: Pediatric patients with diagnosis of retinoblastoma between April 2012 and July 2014 in México City were included for treatment with intra-arterial chemotherapy. Results: Sixteen patients with 25 intra-arterial chemotherapy infusions, one to three sessions each (mean 1.5); seven showed partial response after the first course and five a complete response after the second. Two patients showed progression to eye enucleation and one had a focal cerebral infarction as complication. The response after a third course is still pending to evaluate. Conclusions: Intra-arterial chemotherapy has demonstrated its usefulness in the conservative treatment of intra-ocular retinoblastoma, but the procedure requires a highly specialized personnel and technical equipment. A larger number of cases and a longer follow-up are needed in order to assess the effectiveness and safety of the procedure.


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