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ISSN 2007-4360 (Print)
Asociación Mexicana de Periodontología, Colegio de Periodoncistas A.C

2014, Number 2

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Rev Mex Periodontol 2014; 5 (2)

Primer Lugar en el Concurso de Carteles

Ruíz-Gutiérrez AC, Herrera-Mora MC, Zamora-Pérez AL, Meléndez-Ruíz JL, Martínez-Rodríguez VC, Guerrero-Velázquez C

Language: Spanish
References: 17
Page: 46-50
PDF size: 300.87 Kb.


ABSTRACT

Background: Periodontal disease includes mainly chronic (CP) and aggressive periodontitis (AP), which are characterized by periodontal pockets, loss of the tooth attachment apparatus and alveolar resorption. Pro-inflammatory cytokines as a result of the immune response in periodontitis generate clonal expansion of cells Th (Th1, Th2 and Th17). It has been recently reported that Th17 clones produce IL-17 (cytokine involved in bone loss in conditions such as rheumatoid arthritis and periodontitis). Objective: To determine the levels of IL-17 in gingival crevicular fluid (GCF) samples. Material and methods: We included 21 individuals, seven healthy controls (HC), seven with chronic periodontitis and seven with aggressive periodontitis. In each patient, the gingival index, plaque index, probing depth and clinical attachment level were recorded. The levels of IL-17 were measured in gingival crevicular fluid via ELISA. Results: We found a significant increase in the levels of IL-17 in the GFC of AP and CP patients compared with HC. Conclusions: Our data shows that there are higher concentrations of IL-17 in patients with AP and CP compared to HC, suggesting that IL-17 plays an important role in the pathogenesis and progression of the disease. It is known that IL-17 activates Th17 and osteoclasts that break down bone matrix, as a result of the exacerbated release of inflammatory mediators in periodontitis.


REFERENCES

  1. Craig R, Pernat AM, Pecoits-Filho R, Levin NW, Katanko P. Periodontal diseases and systemic inflammation. Seminars in Dialysis. 2013; 26: 16-39.

  2. Lindhe J, Ranney R, Lamster I et al. Consensus report: chronic periodontitis. Ann Periodontol. 1999; 4: 38-38.

  3. Schmidt-Weber CB, Akdis M, Akdis CA. TH17 cells in the big picture of immunology. J Allergy Clin Immunol. 2007; 120: 247-254.

  4. Sánchez-Hernández PE, Zamora-Pérez AL, Fuentes-Lerma M, Robles-Gómez C, Mariaud-Schmidt RP, Guerrero-Velázquez C. IL-12 and IL18 levels in serum and gingival tissue in aggressive and chronic periodontitis. Oral Dis. 2011; 17: 522-529.

  5. Lockhart E, Green AM, Flynn JL. IL-17 production is dominated by gamma delta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection. J Immunol. 2006 Oct 1; 177(7): 4662-4669.

  6. Ohyama H, Kato-Kogoe N, Kuhara A et al. The involvement of IL-23 and the Th17 pathway in periodontitis. J Dent Res. 2009; 88: 633-638.

  7. Vernal R, Dutzan N, Chaparro A, Puente J, Valenzuela MA, Gamonal J. Levels of interleukin-17 in gingival crevicular fluid and in supernatants of cellular cultures of gingival tissue from patients with chronic periodontitis. J Clin Periodontol. 2005; 32: 383-389.

  8. Schenkein H, Koertge T, Brooks C, Sabatini R, Purkall D, Tew J. IL-17 in sera from patients with aggressive periodontitis. J Dent Res. 2010; 80: 943-947.

  9. Declaración de Helsinki y sus modificaciones en Tokio y Venecia.

  10. Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol. 1999; 4: 1-6.

  11. Silness J, Loe H. Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition. Acta Odontol Scand. 1964; 22: 121-135.

  12. Loe H, Silness J. Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odontol Scand. 1963; 21: 533-551.

  13. Houri-Haddad Y, Wilensky A, Shapira L. T-cell phenotype as a risk factor for periodontal disease. Periodontol 2000. 2007; 45: 67-75.

  14. Kramer JM, Gaffen SL. Interleukin-17: a new paradigm in inflammation, autoimmunity, and therapy. J Periodontol. 2007; 78: 1083-1093.

  15. Anunziato F, Cosmi L, Liotta F, Maggi E, Romagnani S. The phenotype of human Th17 cells and their precursors, the cytokines that mediate their differentiation and the role of Th17 cells in inflammation. Int Inmunology. 2008; 20: 1361-1368.

  16. Ay ZY, Yilmaz G, Ozdem M, Koçak H et al. The gingival crevicular fluid levels of interleukin-11 and interleukin-17 in patients with aggressive periodontitis. J Periodontol. 2012; 83: 1425-1431.

  17. Gupta G. Gingival crevicular fluid as a periodontal diagnostic indicator- II: Inflammatory mediators, host-response modifiers and chair side diagnostic aids. J Med Life. 2013; 6 (1): 7-13.




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