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2014, Number 1

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Rev Med MD 2014; 5.6 (1)

Is there a true relation between dementia and vitamin B12?

Aray-Andrade MM, Navarrete-Borja AC, Villacís-Álava C

Language: Spanish
References: 15
Page: 51-56
PDF size: 545.97 Kb.


ABSTRACT

Introduction. Dementia is a progressive neurological disease that causes cognitive impairment causing limitation in patient’s life. The World Health Organization estimates that 25-29 millions of people have dementia. There are different risk factors like smoking, alcoholism, age, strokes and nutritional deficiencies like vitamin B12 deficiency.
Objective. To analyze through a systematic revision the relation between dementia and the deficiency of vitamin B12, as well as the proper use of vitamin B12 supplements as treatment for cognitive deficiency in advanced age patients.
Material y Methods. A search in the MEDLINE–PUBMED, REDALYC, DIALNET, BIOMED CENTRAL, SciELO, PLOS MEDICINE, Cochrane BVS, EMBASE databases using the sensitive descriptors that may capture all the related studies to dementia and vitamin B12. Thereafter, select the studies showing an important relation.
Results. Only 11 studies showed relation to dementia and vitamin B12; 3 of which were revision articles, 2 were case-control studies, 3 systematic revisions and 3 original articles. In the majority of studies the patients with identified low levels of vitamin B1 received a high dose of the same substance. There is a big variability in the duration of the treatment.
Conclusion. Despite there is no statistically significant data, there is evidence of a group of patients having deficiency of vitamin B12 and developing slight cognitive decline or even dementia. More research is needed on its therapeutic use.


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