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ISSN 2225-4676 (Electronic)

2014, Number 2

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Rev Cubana Neurol Neurocir 2014; 4 (2)

Dorsal spinal extraskeletal Ewing sarcoma: two case report

Mosquera BG, Hernández GEH, Hernández CI, Quintero MO

Language: Spanish
References: 24
Page: 166-173
PDF size: 432.86 Kb.


ABSTRACT

Introduction: Extraskeletal Ewing sarcomas are a rare type of soft tissue tumors and represent the two percent of neoplasm in adults. It is characterized by the aggressiveness, high incidence of local recurrence and metastases. Central nervous system affection is uncommon.
Clinical cases: Two patients of 21 and 27 years old each are presented treated by the Neurosurgery service of the University Hospital “Manuel Ascunce Domenech” of Camagüey in 2012 and 2013. They complaint dorsal pain followed by a dorsal incomplete medullar compression syndrome. The Magnetic Resonance Imaging showed the presence of intraspine tumors, that´s why surgical treatment was mandatory for decompression of neurologic structures and tumor removal. The anatomopathologic diagnosis suggests an extra skeletal Ewing sarcoma and inmunohistochemistry techniques confirmation were required. Two month after surgery, recurrence appeared with unfavorable clinic evolution. Multidrug chemotherapy did not control local reappearance of the disease.
Conclusions: the highly malignance of this kind of tumor required wide removal, supported by transoperatory histopathology to guarantee surgery effectiveness, followed by multidrug chemotherapy to help systemic control and prevent recurrence. The key for better results are a precocious diagnosis before metastases appearance and a multidisciplinary multimodal treatment.


REFERENCES

  1. Silk AW, Schuetze SM. Histology-specific therapy for advanced soft tissue sarcoma and benign connective tissue tumors. Curr Treat Options Oncol. 2012;13(3):285-98. doi: 10.1007/s11864-012-0194-4.

  2. Tuna M, Ju Z, Amos CI, Mills GB. Soft tissue sarcoma subtypes exhibit distinct patterns of acquired uniparental disomy. BMC Med Genomics. 2012;5:60.

  3. Van der Graaf WT, Gelderblom H. New systemic therapy options for advanced sarcomas. Curr Treat Options Oncol. 2012;13(3):306-17. doi: 10.1007/s11864-012-0196-2. G. Mosquera Betancourt et al Rev Cubana Neurol Neurocir. 172 2014;4(2):166–73

  4. Ducimetiere F, Lurkin A, Ranchere Vince D, Decouvelaere AV, Peoch M, Istier L, et al. Incidence of sarcomas histotipes and molecular subtypes in a prospective epidemiological study with central pathology review and molecular testing. PLos One. [internet] 2011 [citado 15 may 2013];6(8): [aprox. 9 p.]. Disponible en: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0020294

  5. Borinstein SC, Beeler N, Block JJ, Gorlick R, Grohar P, Jedlicka P, Krailo M, et al. A decade in banking Ewing sarcoma: a report from the Children’s Oncology Group. [internet] 2013 Mar [citado 23 mar 2013];3(57): [aprox. 8 p.].Disponible en: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602933/pdf/fonc–03–00057.pdf

  6. Somaiah N, von Meheren M. New drugs and combination for the treatment of soft tissue sarcoma: a review. Cancer Manag Res. 2012;4:397–411.

  7. Potratz J, Jürgens H, Craft A, Dirksen U. Ewing sarcoma: biology–based therapeutic perspectives. Pediatr Hematol Oncol. 2012;29(1):12–27.

  8. Kelleher FG, Thomas DM, Molecular pathogenesis and targeted therapeutics in Ewing sarcoma/ primitive neuroectodermal tumours. Clin Sarcoma Research. [internet] 2012 [citado 15 may 2013];2(1): [aprox. 6 p.]. Disponible en: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351706

  9. Bannasch H, Eisenhardt S, Grosu A, Heinz J, Momeni A, Stark B. The diagnosis and treatment of soft tissue sarcomas of the limbs. Dtsch Arztebl Int. 2011;108(3):32–8.

  10. Godoy A, Liuzzi J, Parada D, Herrera J, Machado T, Velásquez Y. Tumor neuroectodérmico primitivo renal. Sarcoma de Ewing extraóseo. Presentación de un caso. Rev Venez Oncol. 2009;21(4):240–43.

  11. Weshi A, Allam A, Ajarim D, Al Dayel F, Pant R, Bazarbashi S, et al. Extraskeletal Ewing's sarcoma family of tumours in adults: analysis of 57 patients from a single institution. Clin Oncol (R Coll Radiol). 2010;22(5):374–81.

  12. Shashikant SP, Gupta K, Malik V, Kumar N, Henke LE, Cal C. Primary Ewing sarcoma of cranial bones: analysis of ten patients. Acta Neurochir. 2011;153:1477–85.

  13. Matten FJ, Nassar A, Bardia A, Jatoi A, Haddock MG, Buckner JC, Lachance DH. Spinal intradural extraoseo Ewing sarcoma. Rare Tumors. 2011;3(1):7.

  14. Vogin G, Biston MC, Marchesi V, Amessis M, De Marzi L, Lacroix F, et al. Localized Ewing sarcoma of the spine: a preliminary dose–escalation study comparing innovative radiation techniques in a single patient. Cancer Radiother. 2013;17(1):26–33.

  15. Tao HT, Hu Y, Wang JL, Cheng Y, Zhang X, Wang H, et al. Extraskeletal ewing sarcomas in late adolescence and adults: a study of 37 patients. Asian Pac J Cancer Prev. 2013;14(5):2967–71.

  16. Martin RC, Brennan MF. Adult soft tissue Ewing sarcoma or primitive neuroectodermal tumors: predictors of survival? Arch Surg. 2003;138(3):281–5.

  17. García Castellano JM, Atallah N, Healey JH, Reyes C. Histopathologic and radiologic assessment of chemotherapeutic response in Ewing sarcoma. A review. Sarcoma. [internet] 2012 Feb [citado 15 may 2013]; 2012(2012): [aprox. 8 p.]. Disponible en: http://www.hindawi.com/journals/srcm/2012/357424/abs

  18. Millan Ecalona E, Corona Pérez R, Ríos Gutiérrez N. Sarcoma de Ewing en un paciente masculino. 2010;26(3):569–75.

  19. Padhye B, McCowage G. Chemotherapy regimens in newly diagnosed and recurrent Ewing sarcoma in children and young adults. Cancer Forum. 2010;34(3):2–7.

  20. Gray ST, Chen YL, Lin DT. Efficacy of Proton Beam Therapy in the Treatment of Ewing's Sarcoma of the Paranasal Sinuses and Anterior Skull Base. Skull Base. 2009;19(6):409–16.

  21. Lissat A, Chao MM, Konty V. Targeted therapy in Ewing sarcoma. ISRN Oncol. [internet] 2012 [citado 15 may 2013];2012(2012): [aprox. 9 p.]. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/22690342

  22. Teicher BA, Bagley R, Rouleau C, Kruger A, Ren Y, Kurtzber L. Characteristics of human Ewing /PNET sarcoma models. Ann Saudi Med. 2011 May–Apr;3(2):174–82.

  23. Subbiah V, Naing A, Brown RE, Chen H, Doyle L, LoRusso P. Targeted Morphoproteomic Profiling of Ewing's Sarcoma Treated with Insulin–Like Growth Factor 1 Receptor (IGF1R) Inhibitors: Response/Resistance Signatures. PLoS One. [internet] 2011 [citado 15 may 2013];6(4):[aprox. 7 p.]. Disponible en: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071831

  24. Raciborska A, Bilska K, Drabko K, Rogowska E, Chaber R, Pogorzala M, et al. Chemotherapy in patients with refractory Ewing sarcoma. Med Wieku Rozwoj. 2013;17(2):117–2




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