2014, Number 3
<< Back Next >>
Rev Cubana Hematol Inmunol Hemoter 2014; 30 (3)
Alogenic platelet lysate in necrosis of the torn piece
Cruz-Sánchez PM, Gámez PA, Rodríguez OCÁ, González-Portales Y, Pérez BM, Arteaga BJM, López GE, González CF, Ricardo SO, Pérez MDS
Language: Spanish
References: 17
Page: 288-293
PDF size: 176.03 Kb.
ABSTRACT
The use of allogenic platelet lysate opens another therapeutic possibility in
orthopedics. Its use is presented in a 40 year-old patient with previous history of
bronchial asthma and treated with steroids who, as a result a fall, suffered an
extensive avulsive wound in her right foot of approximately 11 cm with skin
laceration and necrosis of the torn piece, with vertex distal and proximal base that
only took skin, with another torn piece of similar bodering and a diameter of
approximatety 6 cm. A
toilette and necrectomy of the cyanotic edge was made,
mainly in the vertexes. Confrontation stitches were taken and an extreme fragility
of the skin was observed when carrying this procedure. Treatment with antibiotics
was started and after 48 hours necrosis of two third of the skin of the torn piece
was observed which was not removed for ten days. After removal local therapy with
alogenic platelet lysate was applied on alternate days. Improving of granulation was
observed, but not in the surrounding skin lesion. Then, a perilessional infiltration
with allogenic platelet lysate was made which improved the lesion appearance and
its healing in a period of only 7 days.
REFERENCES
Jiménez Puya R, Rodríguez Bujaldón A, Moreno Giménez JC. Necrosis del colgajo. Piel. 2007;22(06):304-8.
Kim LR, Whelpdale K, Zurowski M, Pomeranz B. Sympathetic denervation impairs epidermal healing in cutaneous wounds. Wound Repair Regen. 1998;6:194-201.
Baum CL, Arpey CJ. Normal cutaneous wound healing: clinical correlation with cellular and molecular events. Dermatol Surg. 2005;31:674-86.
Werner S, Grose R. Regulation of wound healing by growth factors and cytokines. Physiol Rev. 2003;3:835-70.
Ofosu FA, Nyarko KA. Human platelet thrombin receptors. Roles in platelet activation. Hematol/Oncol Clin North Am. 2000;14:1185-98.
Bielsa Marsol I. Proceso de cicatrización de las heridas. Piel. 2006;21:207-12.
Fernández-Delgado N, Hernández-Ramírez P, Forrellat-Barrios M. Espectro funcional de las plaquetas: de la hemostasia a la medicina regenerativa. Rev Cubana Hematol Inmunol Hemoter. 2012 julio-sep;28(3):200-16.
Gámez-Pérez. A, Arteaga-Báez J M, Rodríguez-Orta. C A, Saavedra-Martínez N, González-Cordero F, Sanabria-Negrín JG, et al. Aplicación local de lisado plaquetario en úlceras posflebíticas. Rev Cubana Hematol Inmunol Hemoter. 2012 oct-dic;28(4):374-84.
Gámez-Pérez A, Arteaga-Báez J M. Rodríguez-Orta. C A, López-González, E, González-Cordero F, Rodríguez-Rodríguez E. Ventajas de las plaquetas alogénicas conservadas en el tratamiento de las úlceras de miembros inferiores. Rev Cubana Hematol Inmunol Hemoter. 2013 ene-mar;29(1):104-7.
Balbo R, Avonto I, Marenchino D, Maddalena L, Menardi G, Peano G. Platelet gel for the treatment of traumatic loss of finger substance. Blood Transfus. 2010 Oct;8(4):255-9. doi:10.2450/2009.0129-09
Greppi N, Mazzucco L, Galetti G, Bona F, Petrillo E, Smacchia C, et al. Treatment of recalcitrant ulcers with allogenic platelet gel from pooled platelets in aged hypomobile patients. Biologicals. 2011 Mar;39(2):73-80. doi:10.1016/j.biologicals.2011.01.002
Arnoczky SP. Biologic adjuncts to connective tissue healing. Can we improve Mother Nature's recipe? In: Day AS, ed. LasVegas: AANA specialty day 2009. Las Vegas: AAOS; 2009. p. 101-7.
Zenker S. Le plasma riche en plaquettes (PRP) pour la réjuvénation du visage. J. Med Esth Chir Derm. 2010;XXXVII(148):179-83.
Torabinejad M, Turman M. Revitalization of tooth with necrotic pulp and open apex by using platelet-rich plasma: a case report. J Endod. 2011 Feb;37(2):265-8. doi: 10.1016/j.joen.2010.11.004
Backly RE, Ulivi V, Tonachini L, Cancedda R, Descalzi F, Mastrogiacomo M. Platelet lysate induces in vitro wound healing of human keratinocytes associated with a strong proinflammatory response. Tissue Eng Part A. 2011 Jul;17(13-14): 1787-800. doi: 10.1089/ten.TEA.2010.0729
Plöderl K, Strasser C, Hennerbichler S, Peterbauer-Scherb A, Gabriel C. Development and validation of a production process of platelet lysate for autologous use. Platelets. 2011;22(3):204-9. doi:10.3109/09537104.2010.531304
Gámez Pérez A. Cuba: a particular scene to offer allogenic platelet lysate from save blood. Rev Ciencias Médicas [Internet]. Dic 2011 [citado 27 Feb 2014 ];15(4):3-7. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1561- 31942011000400002&lng=es