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2014, Number 3

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Residente 2014; 9 (3)

Bcl-2: its role in the cell cycle, apoptosis, and cancer

Ramírez-García MÁ, Márquez-González H, Barranco-Lampón G, López-Aguilar JE

Language: Spanish
References: 47
Page: 84-94
PDF size: 276.37 Kb.


ABSTRACT

The cell cycle is a complex process of reproduction that has the ultimate goal of obtaining two identical daughter cells. During this process, the cell determines checkpoints and restrictions to coordinate and avoid the presence of errors that create biologically altered cells. The outcome of all cells that perform a life cycle can be seen in two scenarios: necrosis, an unintended, accidental damage and associated tisular event; or apoptosis, a programmed cell death mechanism, which requires energy. Its activation can take place by the binding of ligands (tumor necrosis factor, fas interleukin-1) or by activating proteins to caspases, allowing the release of cytochrome C into the cytoplasm. The Bcl-2 (B cell Lymphoma) was first described in patients with lymphoma; it is a protein belonging to a family of proteins subclassified into three groups according to their homology and function: proapoptotic or antiapoptotic. Overexpression or silencing of these is closely related to the development and aggressiveness of tumors since it can offer the cancerous cell immortality attributes that can perpetuate its malignancy and obscure its prognosis in presenting little therapeutic response. In the following review, we present the relationship of the Bcl-2 family on cell cycle, apoptosis and cancer.


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