medigraphic.com
ISSN 2007-6053 (Print)
Órgano oficial de difusión de los Hospitales Regionales de Alta Especialidad (HRAE)

2014, Number 2

<< Back Next >>

Evid Med Invest Salud 2014; 7 (2)

Paraneoplastic pemphigus by Castleman disease. A case report

Pérez-Tirado JM, Valenzuela-Barba X, Rábago-Escoto R, Hernández-Cruz LI, Sánchez-González RA, Canseco-Ávila LM

Language: Spanish
References: 17
Page: 89-92
PDF size: 405.94 Kb.


ABSTRACT

Paraneoplastic pemphigus (PNP) is a rare auto immune bullous disease, it is accompanied by histological and immunopathological features, and a set of characteristic autoantibodies. We made the present case from a male patient 21 years old, attended to present painful tongue ulcer enlarged, plus painless generalized erythema, chest radiograph is performed and computed tomography of the mediastinum reporting mediastinal tumor; hospital management starts, take biopsy which reports suprabasal blister with acantholysis and necrosis blister. Is programmed for surgical resection of mediastinal tumor and continue with treatment with corticosteroids and azathioprine.


REFERENCES

  1. Anhalt GJ, Kim SC, Stanley JR, Korman NJ, Jabs DA, Kory M et al. Paraneoplastic pemphigus. An autoimmune mucocutaneous disease associated with neoplasia. New Eng J Med. 1990; 323: 1729-1735.

  2. Mimouni D, Anhalt GJ, Lazarova Z, Aho S, Kazerounian S, Kouba DJ et al. Paraneoplastic pemphigus in children and adolescents. Br J Dermatol. 2002; 147: 725-732.

  3. Zimmerman J, Bahmer F, Rose C et al. Clinical and immunopathological spectrum of paraneoplastic pemphigus. J Dtsch Dermatol Ges. 2010; 8: 598-605.

  4. Robinson ND, Hashimoto T, Amagai M et al. The new pemphigus variants. J Am Acad Dermatol. 1999; 40: 649-671.

  5. Sehgal VN, Srivastava G. Paraneoplastic pemphigus/paraneoplastic autoimmune multiorgan syndrome. Int J Dermatol. 2009; 48: 162-169.

  6. Nguyen VT, Ndoye A, Bassler KD et al. Classification, clinical manifestations and immunopathological mechanisms of the epithelial variant of paraneoplastic autoimmune multiorgan syndrome. Arch Dermatol. 2001; 137: 193-206.

  7. Oursler JR, Labib RS, Ariss-Abdo L et al. Human autoantibodies against desmoplakins in paraneoplastic pemphigus. J Clin Invest. 1992; 89: 1775-1782.

  8. Huang Y, Li J, Zhu X. Detection of anti-envoplakin and anti-periplakin autoantibodies by ELISA in patients with paraneoplastic pemphigus. Arch Dermatol Res. 2009; 301: 703-709.

  9. Cervini, A. B., et al. Pénfigo paraneoplásico/síndrome multiorgánico autoinmune paraneoplásico. Presentación de dos casos en la edad infantil. Revisión de la literatura. Actas Dermosifiliogr. 2010; 101(10):879-886.

  10. Joly P, Richard C, Gilbert D et al. Sensitivity and specificity of clinical, histologic, and immunologic features in the diagnosis of paraneoplastic pemphigus. J Am Acad Dermatol. 2000; 43: 619-626.

  11. Zhu X, Zhang B. Paraneoplastic pemphigus. J Dermatol. 2007; 34 (8): 503-511.

  12. Wakahara M, Kiyohara T, Kumakiri M et al. Paraneoplastic pemphigus with widespread mucosal involvement. Acta Derm Venereol. 2005; 85: 530-532.

  13. Nikolskaia OV, Nousari CH, Anhalt GJ. Paraneoplastic pemphigus in association with Castleman’s disease. Br J Dermatol. 2003; 149: 1143-1151.

  14. Horn TD, Anhalt GJ. Histologic features of paraneoplastic pemphigus. Arch Dermatol. 1992; 128: 1091-1095.

  15. Leger S, Picard D, Ingen-Housz-Oro S et al. Prognostic factors of paraneoplastic pemphigus. Arch Dermatol. 2012; 148: 1165-1172.

  16. Park GT, Lee JH, Yun SJ et al. Paraneoplastic pemphigus without an underlying neoplasm. Br J Dermatol. 2007; 156: 725-732.

  17. Menenakos Ch, Braumann C, Hartmann J, Jacobi CA. Retroperitoneal Castleman’s tumor and paraneoplastic pemphigus: report of a case and review of the literature. World J Surg Oncol. 2007; 5: 45.




2020     |     www.medigraphic.com