medigraphic.com
ISSN 1561-3119 (Electronic)

2014, Number 2

<< Back Next >>

Rev Cubana Pediatr 2014; 86 (2)

Experiences in treating infantile hemangiomas with Cubanmade propranolol

Moredo RE, Pastrana FFM

Language: Spanish
References: 24
Page: 147-158
PDF size: 178.98 Kb.


ABSTRACT

Introduction: infantile hemangiomas are the most frequent tumors in children. Although they are generally benign, its fast growth may turn them into lifethreatening destructive tumors in roughly 1 % of cases. At present, betablockers such as oral propranolol have been used with very good results.
Objectives: to evaluate the effects and safety of Cuban-made propranolol for the treatment of infantile hemangiomas in proliferation phase.
Methods: descriptive applied study of 21 patients with 26 infantile hemangiomas in proliferation phase. It was conducted from December 1st 2010 through June 31st 2012. The patients had been seen at the dermatology department of "Juan Manuel Márquez" teaching pediatric hospital and treated with Cuban-made orally administered propranolol at 2 mg/kg/day divided into 2 sub-doses. They were evaluated every 15 days up to the third month of treatment and monthly up to the 6 months of treatment. Adverse effects were recorded.
Results: few days after the beginning of the treatment, the positive effect was evident in all the cases (favorable changes in staining or size). The adverse effects were slight and self-limited. The response to treatment was good or excellent in 99 % of patients after 6 months of treatment.
Conclusions: the treatment with Cuban-made orally administered propranolol induces rapid improvement of infantile hemangiomas in these children, considerably shortening the natural evolution of these tumors with low secondary effects.


REFERENCES

  1. Drolet BA, Esterly NB, Frieden IJ. Hemangiomas in children. N Engl J Med. 1999;341(3):173-80.

  2. Escutia Muñoz B, Febrer Bosch I. Tratamiento médico de los hemangiomas. Piel. 2002;17(3):139-44.

  3. Cáseres H, Velásquez F. Lesiones vasculares. En: Cáseres H, Velásquez F. Dermatología Pediátrica. Lima: Fondo Editorial del Instituto Nacional para la Salud del Niño; 2010. p. 126-8.

  4. Tumores benignos [homepage en internet]. Madrid, España [citado 30 de octubre de 2009]. Disponible en: http://www.uv.es/derma/

  5. Sánchez Pérez R, Cortes Mora P, González Rodríguez JD, Rodríguez Sánchez F, De la Peña de Torres J. Tratamiento del hemangioma infantil con propranolol. An Pediatr (Barc). 2010;72(2):152-4.

  6. Bozan I, León C, Díaz M, Lago YZ. Comportamiento de los defectos congénitos en el municipio de Cabaiguán. Año 2006-2011. Gaceta Médica Espirituana [serie en Internet]. 2012 [citado 2 de febrero de 2013];14(3). Disponible en: http://revgmespirituana.sld.cu/index.php/gme/article/view/194

  7. Zaher H, Rasheed H, Hegazy RA, Abedelhalim DM, Gawdat HJ. Oral propranolol: an effective, safe treatment for infantile hemangiomas. Eur J Dermatol. 2011;21(4):558-63

  8. Léauté-Labréze C, Hubiche T, Boralevi F, Dumas de la Roque E, Thambo JB, Taibeb A. Les bétabloquates: une alternative á la corticotheérapie générales dans le traitement des hemangiomes infantiles. Comunicación oral. Journées Dermatologique de Paris, Société Française de Dermatologie. Paris, Francia, 4-8 de diciembre de 2007.

  9. Léauté-Labréze C, Hubiche T, Boralevi F, Dumas de la Roque E, Thambo JB, Taibeb A. Propranolol for severe hemangiomas of infancy. N England J Med. 2008;358:2 649-51.

  10. Baselga E. Propranolol for the treatment of infantile hemangiomas of infancy. Poster. 34th Annual Meeting of the Society for Pediatric Dermatology. Snowbird, UT, USA. 9-12 de Julio; 2008.

  11. Cordisco MR. Propranolol en el tratamiento de los hemangiomas. Rev Dermat Ped Latinoamericana. 2008:6(2):95-6.

  12. San V, de la Roque ED, Begel J, Boralevi F, Mazereeuw-Hautier J. Propranolol for severe infantile hemangiomas: follow-up report. Pediatrics. 2009;124:431-2.

  13. Annabi B, Lachambre MP, Plouffe K, Moumdjian R, Beliveau R. Propranolol adrenergic blockade inhibits human brain endothelial cells tubulogenesis and matrix metalloproteinace-9 secretion. Pharmacol Res. 2009;60:438-45.

  14. Moredo E, de la Peña T, Matos VL, Monzón M, Cárdenas MM. Presentación de 3 casos de hemangiomas infantiles tratados con propranolol. Rev Cubana Pediatr [serie en Internet]. 2011 [citado 20 de diciembre de 2012];83(3). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034- 75312011000300012&lng=es&nrm=iso&tlng=es

  15. Moredo E, Pastrana F. Tratamiento exitoso de un hemangioma de parótida con propranolol. Rev Cubana Pediatr [serie en Internet]. 2012 [citado 20 de diciembre de 2012];84(2). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034- 75312012000200011&lng=es&nrm=iso&tlng=es

  16. Metry DW, Hebert AA. Benign Cutaneous Vascular tumors of infancy: When to worry, what to do. Arch Dermatol. 2000;136:905-14.

  17. Kramer D, Muñoz P, Alfaro P, Aranibar L, Cardenas L, Morovic CG, et al. Propranolol en el Tratamiento de los Hemangiomas de la Infancia. Rev Chil Pediatr. 2010;81(6):523-30.

  18. Greco MF, Cardisco MR. Lesiones Vasculares. En: Laralde M, Abad E, Luna P. Dermatología Pediátrica. 2da. ed. Buenos Aires: Ediciones Journal; 2010. p. 505-24.

  19. Weston WL, Lane AT, Morell JG. Lesiones vasculares. En: Dermatología Pediátrica. 4ta. ed. Barcelona: Elsevier; 2008. p. 237-55.

  20. Sánchez R, Cortes P, González JD, Rodríguez F, De la Pena J. Tratamiento del hemangioma infantil con Propranolol. An Pediatr. 2010;72(2):152-4.

  21. Fuchsmann C, Quintal MC, Giguere C. Propranolol as first-line treatment of head and neck hemangiomas. Archives of Otolaryngology-Head and Neck Surgery. 2011:137(5):471-8.

  22. Zvulunov A, McCuaig C, Frieden IJ, Mancini AJ, Puttgen KB, Dohil M, et al. Oral propranolol therapy for infantile hemangiomas beyond the proliferation phase: a multicenter retrospective study. Pediatr Dermatol. 2011 Mar-Apr;28(2):94-8.

  23. Sans V, de la Roque ED, Berge J, Grenier N, Boralevi F, Mazereeuw-Hautier J, et al. Propranolol for severe infantile hemangiomas: follow-up report. Pediatrics. 2009 Sep;124(3):e423-e431.

  24. Bagazgoitia L, Torrelo A, Gutiérrez JC, Hernández-Martín A, Luna P, Gutiérrez M, et al. Propranolol for infantile hemangiomas. Pediatr Dermatol. 2011 Mar- Apr;28(2):108-14.




2020     |     www.medigraphic.com