2014, Number 6
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Cir Cir 2014; 82 (6)
Seroprevalence of antinuclear antibodies in blood donors in the Yaqui Valley
Serrano-Osuna R, López-López RM, Brito-Zurita OR, Sabag-Ruiz E, Pérez-Fernández H, Ornelas-Aguirre HM
Language: Spanish
References: 35
Page: 619-627
PDF size: 426.25 Kb.
ABSTRACT
Background: Antinuclear antibodies are immunoglobulins that
recognize autologous nuclear and cytoplasmic cellular components.
In healthy persons they are not associated with autoimmune disease.
However, they may be related to an immune risk phenotype that has
not been sufficiently studied. We undertook this study to examine the
presence of antinuclear antibodies in serum from blood donors.
Methods: Cross-sectional study on 379 blood donors between 18 and 65
years old. Serum for the presence of antinuclear antibodies by indirect
immunofluorescence in HEp-2 cells was analyzed. The prevalence and
pattern of expression were compared with age, gender, and history of
rheumatic or thyroid disease.
Results: Prevalence of antinuclear antibodies in the study population
was 13%. Most of the positive subjects were between 21 and 40 years
old. Male gender expressed a greater proportion of positivity (11%)
than females (2%). Likewise, 82% of males had low titers (1:80) and
nucleolar type in 66% of cases (OR = 10.66 [1.83 to 62.18],
p = 0.007).
Conclusions: The presence of antinuclear antibodies in healthy
individuals at low levels may not mean an autoimmune condition;
however, it could reflect exposure to environmental factors that have
not been sufficiently studied. New studies of healthy individuals are
necessary in order to explain the association between the presence of
these antibodies and toxic and environmental factors and their effects
on health.
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