2014, Number 08
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MediSan 2014; 18 (08)
Clinical and hystomorphological findings in patients with non alcoholic hepatic steatosis
Caro FMT, Fernández DJ, Martén MD, Barrueco BLB, Diarra O
Language: Spanish
References: 20
Page: 1173-1179
PDF size: 91.99 Kb.
ABSTRACT
An observational and descriptive study of 32 patients with hepatic alcoholic steatosis,
diagnosed in "Saturnino Lora Torres" Teaching Clinical Surgical Provincial Hospital in
Santiago de Cuba was carried out from January, 2011 to June, 2013, in order to
characterize them epidemiologically, clinically and hystomorphologically. In the
investigation an increment of the non alcoholic hepatic steatosis was obtained among the
chronic hepatopathies, with prevalence in people of the age groups 35-44 and 45-54
years and of the male sex, and a higher association to hypertriglyceridemia and
hypertransaminasemia; equally, the dyslipidemia and overweight--according to index of
body mass-- represented the most frequent risk factors in those affected. There was no
statistical significance when correlating the echographical with the biopsy findings, so
that it was reaffirmed that laparoscopy constitutes the most sensitive and specific mean
to diagnose the disease.
REFERENCES
Ludwig J, Viggiano TR, McGill DB, Oh BJ. Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin Proc. 1980; 55(7): 434-82.
Matteoni CA, Younossi ZM, Gramlich T, Boparai N, Liu YC, McCullough AJ. Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology. 1999; 116(6): 1413-9.
Brunt EM, Janney CG, DiBisceglie AM, Neuschwander-Tetri BA, Bacon BR. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol. 1999; 94: 2467-74.
Córdova Pluma VH, Alemán Ortiz G, Cantú Gómez A. Hígado graso no alcohólico: un encuadre didáctico para un problema latente (primera parte). Med Int Mex. 2009; 25(1): 38-57.
Zavala Lugo E, Reyes Rodríguez EA. Hígado graso no alcohólico. Revista de la Escuela de Medicina “Dr. José Sierra Flores”. 2010; 24(2): 28-32.
Méndez Sánchez N, Chávez-Tapia NC, Uribe M. Hígado graso no alcohólico. Nuevos conceptos. Rev Invest Clín. 2004; 56(1): 72-82.
Targher G, Day CP, Bonora E. Enfermedad del hígado graso no alcohólico. N Engl J Med. 2010; 363: 1341-50.
Wolpert Barraza E, Kershenobich Stalnikowitz D. Esteatosis y esteatohepatitis no alcohólica [citado 31 Jul 2013]. Disponible en: http://www.medicinaysalud.unam. mx/temas/2009/08_ago_2k9.pdf
Castellano G, Pérez Carreras M. Esteatosis y esteatohepatitis no alcohólica. En: Asociación Española para el Estudio del Hígado. Tratamiento de las enfermedades hepáticas y biliares. Madrid: AEEH; 2001.
Almarza J. Hígado graso no alcohólico: ¿un componente inflamatorio del síndrome metabólico? Perspect Nutr Hum. 2010; 12(2): 163-75.
Tessari P, Coracina A, Cosma A, Tiengo A. Hepatic lipid metabolism and nonalcoholic fatty liver disease. Nutr Metab Cardiovasc Dis. 2009; 19(4): 291-302.
Puri P, Baillie RA, Wiest MM, Mirshahi F, Choudhury J, Cheung O, et al. A lipidomic analysis of nonalcoholic fatty liver disease. Hepatology. 2007; 46(4): 1081-90.
Fassio E, Alvarez E, Domínguez N, Landeira G, Longo C. Natural history of nonalcoholic steatohepatitis: a longitudinal study of repeat liver biopsies. Hepatology. 2004; 40(4): 820-6.
Casal Esteban V, Barbado Hernández FJ, Vázquez Rodríguez JJ, Rodríguez Molinero MA, Larrauri J, López-Diéguez Puerta M, et al. Esteatohepatitis no alcohólica, el enigma de una mala evolución. An Med Interna. 2005; 22(2): 85-7.
Sanyal AJ, Contos MJ, Sterling RK, Luketic VA, Shiffman ML, Stravitz RT, et al. Nonalcoholic fatty liver disease in patients with hepatitis C is associated with features of the metabolic syndrome. Am J Gastroenterol. 2003; 98(9): 2064-71.
Taylor KJ, Riely CA, Hammers L, Flax S, Weltin G, Garcia-Tsao G. Quantitative US attenuation in normal liver and in patients with diffuse liver disease: importance of fat. Radiology. 1986; 160(1): 65-71.
Pérez Lorenzo M, Franco Estrada S, Winograd Lay R, Angulo Pérez O. Aspectos clínico-patológicos del hígado graso no alcohólico. Rev Cubana Med Mil. 2003 [citado 18 Jun 2013]; 32(4). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_ arttext&pid=S0138-65572003000400005
Bacon BR, Farahvash MJ, Janney CG, Neuschwander-Tetri BA. Nonalcoholic steatohepatitis: an expanded clinical entity. Gastroenterology. 1994; 107(4): 1103- 9.
Sorbi D, Boynton J, Lindor KD. The ratio of aspartate aminotransferase to alanine: potential value in differentiating nonalcoholic steatohepatitis from alcoholic liver disease. Am J Gastroenterol. 1999; 94(4): 1018-22.
Saverymuttu SH, Joseph AE, Maxwell JD. Ultrasound scanning in the detection of hepatic fibrosis and steatosis. Br Med J (Clin Res Ed). 1986; 292(6512): 13–5.