Kuder H, Lover G, Lugo Y, Espinoza M, Coccione S

Language: Spanish
References: 20
Page: 1152-1157
PDF size: 272.11 Kb.

ABSTRACT

A descriptive study of 129 neonates of both sexes, born in the Neonatology Unit of a Public Health Center from Puerto Cabello city, Venezuelan state of Carabobo, was carried out from January, 2012 to June, 2013, in order to detect early newborns with hemoglobin S. In the series the feminine sex prevailed (51.9%). The electrophoresis technique was used and normal hemoglobin (Hb A) was found in 91.5%, as well as electrophoretic patterns of abnormal hemoglobin compatible with Hb S in 8.5%. Of the 11 positive cases, 90.9% corresponded to Hb SA and 9.1% to Hb SS. The detected hemoglobin SA and SS frequency, even when diagnostic results could not be established, represented a warning to implement the early detection, which conducted to a program of early prevention, and to prophylaxis from the first months of life.

REFERENCES

1. Sáenz Renauld GF. Hemoglobinopatías en los países de la cuenca del Caribe. Rev Biol Trop. 1988;36(2b):361.

2. Martini G, Bastos BM, Santos N, Oliveira C, Ruhland L, Da Silva PH, et al. Triagem neonatal e hemoglobinopatias em Santa Catarina, Brasil. Rev Bras Anal Clin. 2009;41(3):185-9.

3. WHO Working Group. Hereditary anaemias: genetic basis, clinical features, diagnosis, and treatment. Bull World Health Organ. 1982;60(5):643-60.

4. Hoppe CC. Prenatal and newborn screening for hemoglobinopathies. Int Jnl Lab. Hem. 2013;35:297–305.

5. Heredero L, Granda h, Altland K. Una solución técnica para hacer un pesquisaje de hemoglobinas a gran escala. Rev Cubana Pediatr. 1974;46:213.

6. Sociedad Española de Hematología y Oncología Pediátricas. Guía de práctica clínica sobre Enfermedad De Células Falciformes Pediátrica. España: SEHOP;2010:7-90.

7. Dulín Iñiguez E, Espada M, Eguileor Gurtubai I. Programas de cribado neonatal. An Pediatr Contin. 2006;4(1):61-5.

8. Clarke GM, Higgins TN. Laboratory investigation of hemoglobinopathies and thalassemias: review and update. Clin Chem. 2000;46 (8-2):1284-90.

9. Hoppe CC. Newborn screening for non-sickling hemoglobinopathies. Hematology Am Soc Hematol Educ Program. 2009:19-25.

10. Arends T. Epidemiología de las variantes hemoglobínicas en Venezuela. Gaceta Med. Caracas. 1984;92:189-224.

11. Arends A, Chacín M, Bravo Urquiola M, Montilla S, Guevara JM, Velásquez D, et al. Hemoglobinopatías en Venezuela. Interciencia. 2007;32(8):516-521.

12. Felix AA, Souza HM, Ribeiro SB. Aspectos epidemiológicos e sociais da doença falciforme. Rev Bras Hematol Hemoter. 2010;32(3):203-8.

13. Hoppe CC. Newborn screening for hemoglobin disorders. Hemoglobin. 2011;35(5- 6):556-64.

14. Selekman J. Update: new guidelines for the treatment of infants with sickle cell disease. Agency for Health Care Policy and Reasearch. Pediatr Nurs. 1993;19(6):600-5.

15. Varela I, Sequera A, Olivero R. Detección de hemoglobinopatías en recién nacidos del Hospital Materno Infantil “Dr. José María Vargas” de la ciudad de Valencia, Venezuela. Salus. 2013;17(2):6-11.

16. Pineda de Del Villar L, Borjas L. La hemoglobina S en Isla de Toas: es un problema genético de salud pública? Invest Clín. 1986;27(1):5-14.

17. Rodríguez E, Silva L, Barbato V, Carrasquero E, Anchustegui M, Arends A. Frecuencia de drepanocitos en varias poblaciones de Barlovento. Gac Med Caracas. 1984:33-44.

18. García O, Chacín M, Bravo M, Gómez G, Montilla S, Merzón R, et al. Diagnóstico de hemoglobinopatías a partir de sangre del talón de recién nacidos en diferentes centros hospitalarios de Venezuela. An Pediatr. 2009;71(4):314-8.

19. Michlitsch J, Azimi M, Hoppe C, Walters MC, Lubin B, Lorey F, et al. Newborn screening for hemoglobinopathies in California. Pediatr Blood Cancer. 2009; 52(4):486-90.

20. Peñaloza Espinosa RI, Buentello Malo L, Hernández Maya MA, Nieva García B, Lisker Yurkowitzki R, Salamanca Gómez F. Hemoglobin S frequency in five Mexican populations and its importance in public health. Salud Publica Mex. 2008;50(4):325-9.