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2014, Number 4

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Rev Mex Patol Clin Med Lab 2014; 61 (4)

Carrion Disease

Márquez SCE, García ERM, León VJL, Rosiles MR

Language: Spanish
References: 26
Page: 246-252
PDF size: 873.42 Kb.


ABSTRACT

Carrion’s disease or human bartonellosis evoke a part of Peruvian medicine history. Also known as Oroya’s fever or Peruvian wart, both denominations refers to the clinical phases of the disease in humans. The first febrile phase or anaemic phase, with high fatality rates of untreated cases, a second phase asintomatic and a third phase of wart cutaneous eruption. It’s caused by Bartonella bacilliformis, Gram negative bacteria with affinity for red blood and endothelial cells. Transmitted by the bite of and infected female sandfly Lutzomyia spp. The presence of the vector is confined to inter Andean valleys, at altitudes between 500 and 3,000 m above sea level; there are case reports in Ecuador, Colombia and Peru, defined as a endemic area. This neglected disease for many years takes importance due the suggestions of an expanding ecological nich. Now retakes importance a correct and opportune diagnostic, starting with a clinical suspect and the aid of laboratory with classic techniques as the blood smear, immunoassays or molecular tests.


REFERENCES

  1. Maguiña C. Nuevas contribuciones al estudio de Bartonelosis o Enfermedad de Carrión. Bol Soc Per Med Int. 1993; 6: 68-85.

  2. Sánchez CN, Ugarte-Gil CA, Solórzano N, Maguiña C, Pachas P, Blazes D et al. Bartonella bacilliformis: A Systematic Review of the Literature to Guide the Research Agenda for Elimination-PLoS Neglected Tropical Diseases, 2012; DOI: 10,1371/journal.pntd.00001819.

  3. Pachas P. La Bartonelosis en el Perú. Lima: Oficina General de Epidemiología – Instituto Nacional de Salud; 2000. Serie de módulos técnicos.

  4. Schultz MG. A history of bartonellosis (Carrion’s disease). Am J Trop Med Hyg. 1968; 17 (4): 503-515.

  5. Strong RP, Tyzzer EE, Brues CT, Sellards AW, Gastiaburu JC. Report of the first expedition to South America. Harvard University Press, Cambridge, MA. 1915.

  6. Brenner DJ, O’Connor SP, Hollis DG, Weaver RE, Steigerwalt AG. Molecular characterization and proposal of a neotype strain for Bartonella bacilliformis. J Clin Microbiol. 1991; 29: 1299-1302.

  7. Gonzales C, Maguiña C, Heras F, Conde-Salazar L. Bartonelosis (Fiebre de la Oroya o Verruga Peruana) ¿Enfermedad ocupacional? Med Segur Trab. 2007; LIII (209): 35-41.

  8. Battisti JM, Minnick MF. Development of a System for Genetic Manipulation of Bartonella bacilliformis. Appl Environ Microbiol. 1999; 65 (8): 3441-3448.

  9. Derrick SC, Ihler GM. Deformin, a substance found in Bartonella bacilliformis culture supernatants, is a small, hydrophobic molecule with an affinity for albumin. Blood Cells Mol Dis. 2001; 27 (6): 1013-1019.

  10. Buckles EL, McGinnis Hill E. Interaction of Bartonella bacilliformis with human erythrocyte membrane proteins. Microb Pathog. 2000; 29 (3): 165-174.

  11. Mitchell SJ, Minnick MF. Characterization of a two-gene locus from Bartonella bacilliformis associated with the ability to invade human erythrocytes. Infect Immun. 1995; 63: 1552-1562.

  12. Coleman SA, Minnick MF. Establishing a direct role for the Bartonella bacilliformis invasin-associated locus B (lalB) protein in human erythrocyte parasitism. Infect Immun. 2001; 69: 4373-4381.

  13. Hill EM, Raji A, Valenzuela MS, García F, Hoover R. Adhesion to an invasión of cultured huamn cell by Bartonella bacilliformis. Infect Immun. 1992; 60: 4051-4058.

  14. Verma A, Davis GE, Ihler GM. Infection of human endothelial cells with Bartonella bacilliformis is dependent on Rho and results in activation of Rho. Infect Immun. 2000; 68: 5960-5969.

  15. Cerimele F, Brown LF, Bravo F, Ihler M, Kouadio P, Arbiser J. Infectious angiogenesis: Bartonella bacilliformis infection results in endothelial production of angiopoetin-2 and epidermal production of vascular endothelial growth factor. Am J Pathol. 2003; 163 (4): 1321-1327.

  16. Maguiña C, García PJ, Gotuzzo E, Cordero L, Spach DH. Bartonellosis (Carrión’s Disease) in the Modern Era. Infect Dis Clin North Am. 2001; 14: 1-22.

  17. Gray GC, Johnson AA, Thornton SA, Smith WA, Knobloch J, Kelley PW et al. An epidemic of Oroya fever in the Peruvian Andes. Am J Trop Med Hyg. 1990; 42: 215-221.

  18. Ellis BA, Rotz LD, Leake JA, Samalvides F, Bernable J et al. An outbreak of acute bartonellosis (Oroya fever) in the Urubamba region of Peru. Am J Trop Med Hyg. 1999; 61: 344-349.

  19. Ventura G, Padilla C. Diagnóstico bacteriológico de la bartonelosis humana o enfermedad de Carrión. Instituto Nacional de Salud. Ministerio de Salud. Lima 2006.

  20. Mallqui V, Spellmon E, Verastegui M, Maguiña C, Pinell-Salles P, Lavarello R et al. Sonicated diagnostic immunoblot for bartonellosis. Clin Diagn Lab Immunol. 2000; 7 (1): 1-5.

  21. Padilla C, Gallegos K, Marcelo A, Chenet S, Baldeviano C. Expresión y serorreactividad de la lipoproteína recombinante 43kDa de Bartonella bacilliformis. Rev Peru Med Exp Salud Pública. 2006; 23: 182-187.

  22. Padilla C, Ventura E. Diseño y estandarización de una prueba de PCR para el diagnóstico de la bartonelosis causada por Bartonella bacilliformis. Rev Perú Med Exp Salud Publica. 2003; 20 (1): 5-8.

  23. Chamberlin J, Laughlin L, Gordon S, Romero S, Solórzano N et al. Serodiagnosis of Bartonella bacilliformis infection by indirect fluorescence antibody assay: test development and application to a population in an area of bartonellosis endemicity. J Clin Microbiol. 2000; 38: 4269-4271.

  24. Knobloch J, Solano L, Alvarez O, Delgado A. Antibodies to Bartonella bacilliformis as determinated by fluorescence antibody test, indirect haemogglutination and ELISA. Trop Med Parasit. 1985; 36: 183-185.

  25. Maguiña C, Romero I, Soto N et al. Historia natural de la fase eruptiva de la Verruga Peruana y la importancia del Western Blot, reporte preliminar. Folia Dermatológica Peruana. 2002; 13 (2): 36-42.

  26. Maguiña C, Ordaya E. Capítulo 54. Verruga Peruana (Enfermedad de Carrión). Publicado en: piel-latinoamericana/Libreria. (Dermatologia Ibero-Americana Online). www.piel-l.org




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