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2014, Number 5

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Rev Med Inst Mex Seguro Soc 2014; 52 (5)

Premature twins: clinic comparison, reproductive assisted techniques versus spontaneous conception

Iglesias-Leboreiro J, Bernardez-Zapata I

Language: Spanish
References: 78
Page: 544-549
PDF size: 77.41 Kb.


ABSTRACT

Background: Twin pregnancies occur one out of every 800. Due to the increase in maternal age and infertility, the use of assisted reproductive technology (ART) has risen. Thirty fi ve percent of pregnancies solved using ART are twin pregnancies. ART consists of infertility treatments in which oocytes and sperm are manipulated. The objective of this study was to compare the clinical behavior of premature twins born through ART versus those born after spontaneous conception (SC).
Methods: Retrolective cohort study. The data was obtained from the records of preterm twins born between August 2010 and August 2013. Preterm twins were categorized in two groups: the ones conceived using ART versus those conceived through SC. Demographic characteristics and neonatal outcomes were compared.
Results: The total was of 398 patients: 208 conceived in consequence of ART and 190 through SC. The primary outcome and neonatal morbidities showed no signifi cant difference, only the incidence of necrotizing enterocolitis and the use of parenteral nutrition showed signifi cant difference. The length of hospital stay between groups was similar.
Conclusion: In our population of preterm twins, the mode of conception had no detectable effect on mortality or short term morbidities.


REFERENCES

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  2. Yang H, Choi YS, Nam KH, Kwon JY, Park YW, Kim YH. Obstetric and perinatal outcomes of dichorionic twin pregnancies according to methods of conception: Spontaneous versus in-vitro fertilization. Twin Res Hum Genet. 2011 Feb;14(1):98-103. doi: 10.1375/twin.14.1.98.

  3. Antsaklis A, Anastasakis E. Selective reduction in twins and multiple pregnancies. J Perinat Med. 2011 Jan;39(1):15-21. doi: 10.1515/JPM.2010.114. Epub 2010 Dec 8.

  4. Daniel Y, Ochshorn Y, Fait G, Geva E, Bar-Am A, Lessing JB. Analysis of 104 twin pregnancies conceived with assisted reproductive technologies and 193 spontaneously conceived twin pregnancies. Fertil Steril. 2000 Oct;74(4):683-9.

  5. Ochsenkuhn R, Strowitzki T, Gurtner M, Strauss A, Schulze A, Hepp H et al. Pregnancy complications, obstetric risks, and neonatal outcome in singleton and twin pregnancies after GIFT and IVF. Arch Gynecol Obstet 2003. 268:256-61. DOI 10.1007/ s00404-003-0518-5.

  6. Janvier A, Spelke B, and Barrington K. The epidemic of multiple gestations and neonatal intensive care unit use: The cost of irresponsibility. J Pediatr. 2011;159:409–413. doi: 10.1016/j.jpeds.2011.02.017.

  7. Allen-Merritt A, Lavery A, June-Anne G, Robin C, and Oshiro B. Assisted reproductive technologies: The need for multi-disciplinary review of its impact on neonatal/perinatal medicine and medical genetics. Neoreviews 2013; 14:e360-e368; doi:10.1542/ neo.14-7-e360.

  8. Wisborg K, Ingerslev HJ, and Brink-Henriksen T. In vitro fertilization and preterm delivery, low birth weight and admission to the neonatal intensive care unit: a prospective follow-up study. Fertil Steril. 2010 Nov;94(6):2102-6. doi: 10.1016/j. fertnstert.2010.01.014.

  9. Sims ME. Legal briefs: The misfortune of monochorionic twins. Neoreviews. 2013;14:e262-e264.

  10. Angelo D, Whitehead N, Helms K, Barfi eld W, and Ahluwalia I. Birth outcomes of intended pregnancies among women who used assisted reproductive technology, ovulation stimulation, or no treatment. Fertil Steril. 2011 Aug;96(2):314-320.e2. doi: 10.1016/j. fertnstert.2011.05.073.

  11. Boulet S, Schieve L, Nannini A, Ferre C, Devine O, Cohen B, et al. Perinatal outcomes of twin births conceived using assisted reproduction technology: a population-based study. Hum Repr0d. 2008:23:1941- 8. doi:10.1093/humrep/den169.

  12. Pinborg A, Loft A, Schmidt L, Langhoff-Roos J, and Andersen A. Maternal risks and perinatal outcome in a Danish national cohort of 1005 twin pregnancies: the role of in vitro fertilization. Acta Obstet Gynecol Scand. 2004 Jan;83(1):75-84

  13. Cowan, J., & Demmer, L. Assisted reproductive technology and preimplantation genetic diagnosis: Impact on the fetus and newborn. Neoreviews March 2007; 8:e127-e132; doi:10.1542/neo.8-3-e127

  14. Shah V, Alwassia H, Shah K, Yoon W, and Shah P. Neonatal outcomes among multiple < 32 weeks gestational age: Does mode of conception have an impact? BMC Pediatr. 2011 Jun 14;11:54. doi: 10.1186/1471-2431-11-54.

  15. Bromer J, Ata B, Seli M, Lockwood C, Seli E. Preterm deliveries that result from multiple pregnancies associated with assisted reproductive technologies in the USA: a cost analysis. Curr Opin Obstet Gynecol. 2011;23:168-73.

  16. Dickey R, Xiong X, Gee R, and Pridjian G. Effect of maternal height and weight on risk of preterm birth in singleton and twin births resulting from in vitro fertilization: a retrospective cohort study using the Society for Assisted Reproductive Technology Clinic Outcome Reporting System. Fertil Steril. 2012 Feb;97(2):349-54. doi: 10.1016/j. fertnstert.2011.11.017.

  17. Weghofer A, Klein K, Stammler-Safar M, Barad D, Worda C, Husslein P, et al. Severity of prematurity risk in spontaneous and in vitro fertilization twins: does conception mode serve as a risk factor? Fertil Steril. 2009 Dec;92(6):2116-8. doi: 10.1016/j. fertnstert.2009.05.087.

  18. Weghofer A, Klein K, Stammler-Safar M, Worda C, Barad D, Husslein P, et al. Can prematurity risk in twin pregnancies after in vitro fertilization be predicted? A retrospective study. Reprod Biol Endocrinol. 2009;7:136.

  19. Beydoun H, Ugwu B, and Oehninger S. Assisted reproduction for the validation of gestational age assessment methods. Reproductive BioMedicine Online. 2011;22:321-6. DOI:10.16/j.rbmo.2010.12.003

  20. Lee K. Fertility treatments and the cost of a healthy baby. Nursing for womens health. 2011;15(1):15-18.

  21. Barri P, Cololeu B, Clua E, Tur R. Prevention of prematurity by single embryo transfer. J Perinat Med. 2011;39:237-40. DOI 10.1515/JMP.2010.020

  22. Nelson S, Lawlor D. Predicting live birth, preterm delivery, and low birth weight in infants born from in vitro fertilization: A prospective study of 144,018 treatment cycles. Plos Med. 2011:8:e1000386

  23. Morcel K, Lavoue V, Beuchee A, Le lannou D, Poulain P, Pladys P. Perinatal morbidity and mortality in twin pregnancies with dichorionic placentas following assisted reproductive techniques or ovarian induction alone: a comparative study. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2010; 153:138-142.

  24. Chong CU, Huang LS, Lee TH, Liu CH, Shih YT, Lee MS. A comparison of the outcomes between twin and reduced twin pregnancies produced through assisted reproduction. Fertil Steril. 2007 Jul;88(1):47-52. DOI: 10.1016/j.fertnstert.2006.11.084.

  25. Ombelet W, Martens G, De-Sutter P, Gerris J, Bosmans E, Ruyssinck G, et al. Perinatal outcome of 12,021 singleton and 3,108 twin births after non- IVF-assisted reproduction: a cohort study. Hum Reprod. 2006 Apr;21(4):1025-32. DOI:10.1093/humrep/ dei419.

  26. Fenton TR. A new growth chart for preterm babies: Babson and Brenda’s chart updated with recent data and a new format. BMC Pediatr. 2003 Dec 16;3:13.

  27. Corsello G, Piro E. The world of twins: an update. J Matern Fetal Neonatal Med. 2010 Oct;23 Suppl 3:59- 62. doi: 10.3109/14767058.2010.508218.

  28. Yang H, Choi YS, Nam KH, Kwon JY, Park YW, Kim YH. Obstetric and perinatal outcomes of dichorionic twin pregnancies according to methods of conception: Spontaneous versus in-vitro fertilization. Twin Res Hum Genet. 2011 Feb;14(1):98-103. doi: 10.1375/twin.14.1.98.

  29. Antsaklis A, Anastasakis E. Selective reduction in twins and multiple pregnancies. J Perinat Med. 2011 Jan;39(1):15-21. doi: 10.1515/JPM.2010.114. Epub 2010 Dec 8.

  30. Daniel Y, Ochshorn Y, Fait G, Geva E, Bar-Am A, Lessing JB. Analysis of 104 twin pregnancies conceived with assisted reproductive technologies and 193 spontaneously conceived twin pregnancies. Fertil Steril. 2000 Oct;74(4):683-9.

  31. Ochsenkuhn R, Strowitzki T, Gurtner M, Strauss A, Schulze A, Hepp H et al. Pregnancy complications, obstetric risks, and neonatal outcome in singleton and twin pregnancies after GIFT and IVF. Arch Gynecol Obstet 2003. 268:256-61. DOI 10.1007/ s00404-003-0518-5.

  32. Janvier A, Spelke B, and Barrington K. The epidemic of multiple gestations and neonatal intensive care unit use: The cost of irresponsibility. J Pediatr. 2011;159:409–413. doi: 10.1016/j.jpeds.2011.02.017.

  33. Allen-Merritt A, Lavery A, June-Anne G, Robin C, and Oshiro B. Assisted reproductive technologies: The need for multi-disciplinary review of its impact on neonatal/perinatal medicine and medical genetics. Neoreviews 2013; 14:e360-e368; doi:10.1542/ neo.14-7-e360.

  34. Wisborg K, Ingerslev HJ, and Brink-Henriksen T. In vitro fertilization and preterm delivery, low birth weight and admission to the neonatal intensive care unit: a prospective follow-up study. Fertil Steril. 2010 Nov;94(6):2102-6. doi: 10.1016/j. fertnstert.2010.01.014.

  35. Sims ME. Legal briefs: The misfortune of monochorionic twins. Neoreviews. 2013;14:e262-e264.

  36. Angelo D, Whitehead N, Helms K, Barfi eld W, and Ahluwalia I. Birth outcomes of intended pregnancies among women who used assisted reproductive technology, ovulation stimulation, or no treatment. Fertil Steril. 2011 Aug;96(2):314-320.e2. doi: 10.1016/j. fertnstert.2011.05.073.

  37. Boulet S, Schieve L, Nannini A, Ferre C, Devine O, Cohen B, et al. Perinatal outcomes of twin births conceived using assisted reproduction technology: a population-based study. Hum Repr0d. 2008:23:1941- 8. doi:10.1093/humrep/den169.

  38. Pinborg A, Loft A, Schmidt L, Langhoff-Roos J, and Andersen A. Maternal risks and perinatal outcome in a Danish national cohort of 1005 twin pregnancies: the role of in vitro fertilization. Acta Obstet Gynecol Scand. 2004 Jan;83(1):75-84

  39. Cowan, J., & Demmer, L. Assisted reproductive technology and preimplantation genetic diagnosis: Impact on the fetus and newborn. Neoreviews March 2007; 8:e127-e132; doi:10.1542/neo.8-3-e127

  40. Shah V, Alwassia H, Shah K, Yoon W, and Shah P. Neonatal outcomes among multiple < 32 weeks gestational age: Does mode of conception have an impact? BMC Pediatr. 2011 Jun 14;11:54. doi: 10.1186/1471-2431-11-54.

  41. Bromer J, Ata B, Seli M, Lockwood C, Seli E. Preterm deliveries that result from multiple pregnancies associated with assisted reproductive technologies in the USA: a cost analysis. Curr Opin Obstet Gynecol. 2011;23:168-73.

  42. Dickey R, Xiong X, Gee R, and Pridjian G. Effect of maternal height and weight on risk of preterm birth in singleton and twin births resulting from in vitro fertilization: a retrospective cohort study using the Society for Assisted Reproductive Technology Clinic Outcome Reporting System. Fertil Steril. 2012 Feb;97(2):349-54. doi: 10.1016/j. fertnstert.2011.11.017.

  43. Weghofer A, Klein K, Stammler-Safar M, Barad D, Worda C, Husslein P, et al. Severity of prematurity risk in spontaneous and in vitro fertilization twins: does conception mode serve as a risk factor? Fertil Steril. 2009 Dec;92(6):2116-8. doi: 10.1016/j. fertnstert.2009.05.087.

  44. Weghofer A, Klein K, Stammler-Safar M, Worda C, Barad D, Husslein P, et al. Can prematurity risk in twin pregnancies after in vitro fertilization be predicted? A retrospective study. Reprod Biol Endocrinol. 2009;7:136.

  45. Beydoun H, Ugwu B, and Oehninger S. Assisted reproduction for the validation of gestational age assessment methods. Reproductive BioMedicine Online. 2011;22:321-6. DOI:10.16/j.rbmo.2010.12.003

  46. Lee K. Fertility treatments and the cost of a healthy baby. Nursing for womens health. 2011;15(1):15-18.

  47. Barri P, Cololeu B, Clua E, Tur R. Prevention of prematurity by single embryo transfer. J Perinat Med. 2011;39:237-40. DOI 10.1515/JMP.2010.020

  48. Nelson S, Lawlor D. Predicting live birth, preterm delivery, and low birth weight in infants born from in vitro fertilization: A prospective study of 144,018 treatment cycles. Plos Med. 2011:8:e1000386

  49. Morcel K, Lavoue V, Beuchee A, Le lannou D, Poulain P, Pladys P. Perinatal morbidity and mortality in twin pregnancies with dichorionic placentas following assisted reproductive techniques or ovarian induction alone: a comparative study. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2010; 153:138-142.

  50. Chong CU, Huang LS, Lee TH, Liu CH, Shih YT, Lee MS. A comparison of the outcomes between twin and reduced twin pregnancies produced through assisted reproduction. Fertil Steril. 2007 Jul;88(1):47-52. DOI: 10.1016/j.fertnstert.2006.11.084.

  51. Ombelet W, Martens G, De-Sutter P, Gerris J, Bosmans E, Ruyssinck G, et al. Perinatal outcome of 12,021 singleton and 3,108 twin births after non- IVF-assisted reproduction: a cohort study. Hum Reprod. 2006 Apr;21(4):1025-32. DOI:10.1093/humrep/ dei419.

  52. Fenton TR. A new growth chart for preterm babies: Babson and Brenda’s chart updated with recent data and a new format. BMC Pediatr. 2003 Dec 16;3:13.

  53. Corsello G, Piro E. The world of twins: an update. J Matern Fetal Neonatal Med. 2010 Oct;23 Suppl 3:59- 62. doi: 10.3109/14767058.2010.508218.

  54. Yang H, Choi YS, Nam KH, Kwon JY, Park YW, Kim YH. Obstetric and perinatal outcomes of dichorionic twin pregnancies according to methods of conception: Spontaneous versus in-vitro fertilization. Twin Res Hum Genet. 2011 Feb;14(1):98-103. doi: 10.1375/twin.14.1.98.

  55. Antsaklis A, Anastasakis E. Selective reduction in twins and multiple pregnancies. J Perinat Med. 2011 Jan;39(1):15-21. doi: 10.1515/JPM.2010.114. Epub 2010 Dec 8.

  56. Daniel Y, Ochshorn Y, Fait G, Geva E, Bar-Am A, Lessing JB. Analysis of 104 twin pregnancies conceived with assisted reproductive technologies and 193 spontaneously conceived twin pregnancies. Fertil Steril. 2000 Oct;74(4):683-9.

  57. Ochsenkuhn R, Strowitzki T, Gurtner M, Strauss A, Schulze A, Hepp H et al. Pregnancy complications, obstetric risks, and neonatal outcome in singleton and twin pregnancies after GIFT and IVF. Arch Gynecol Obstet 2003. 268:256-61. DOI 10.1007/ s00404-003-0518-5.

  58. Janvier A, Spelke B, and Barrington K. The epidemic of multiple gestations and neonatal intensive care unit use: The cost of irresponsibility. J Pediatr. 2011;159:409–413. doi: 10.1016/j.jpeds.2011.02.017.

  59. Allen-Merritt A, Lavery A, June-Anne G, Robin C, and Oshiro B. Assisted reproductive technologies: The need for multi-disciplinary review of its impact on neonatal/perinatal medicine and medical genetics. Neoreviews 2013; 14:e360-e368; doi:10.1542/ neo.14-7-e360.

  60. Wisborg K, Ingerslev HJ, and Brink-Henriksen T. In vitro fertilization and preterm delivery, low birth weight and admission to the neonatal intensive care unit: a prospective follow-up study. Fertil Steril. 2010 Nov;94(6):2102-6. doi: 10.1016/j. fertnstert.2010.01.014.

  61. Sims ME. Legal briefs: The misfortune of monochorionic twins. Neoreviews. 2013;14:e262-e264.

  62. Angelo D, Whitehead N, Helms K, Barfi eld W, and Ahluwalia I. Birth outcomes of intended pregnancies among women who used assisted reproductive technology, ovulation stimulation, or no treatment. Fertil Steril. 2011 Aug;96(2):314-320.e2. doi: 10.1016/j. fertnstert.2011.05.073.

  63. Boulet S, Schieve L, Nannini A, Ferre C, Devine O, Cohen B, et al. Perinatal outcomes of twin births conceived using assisted reproduction technology: a population-based study. Hum Repr0d. 2008:23:1941- 8. doi:10.1093/humrep/den169.

  64. Pinborg A, Loft A, Schmidt L, Langhoff-Roos J, and Andersen A. Maternal risks and perinatal outcome in a Danish national cohort of 1005 twin pregnancies: the role of in vitro fertilization. Acta Obstet Gynecol Scand. 2004 Jan;83(1):75-84

  65. Cowan, J., & Demmer, L. Assisted reproductive technology and preimplantation genetic diagnosis: Impact on the fetus and newborn. Neoreviews March 2007; 8:e127-e132; doi:10.1542/neo.8-3-e127

  66. Shah V, Alwassia H, Shah K, Yoon W, and Shah P. Neonatal outcomes among multiple < 32 weeks gestational age: Does mode of conception have an impact? BMC Pediatr. 2011 Jun 14;11:54. doi: 10.1186/1471-2431-11-54.

  67. Bromer J, Ata B, Seli M, Lockwood C, Seli E. Preterm deliveries that result from multiple pregnancies associated with assisted reproductive technologies in the USA: a cost analysis. Curr Opin Obstet Gynecol. 2011;23:168-73.

  68. Dickey R, Xiong X, Gee R, and Pridjian G. Effect of maternal height and weight on risk of preterm birth in singleton and twin births resulting from in vitro fertilization: a retrospective cohort study using the Society for Assisted Reproductive Technology Clinic Outcome Reporting System. Fertil Steril. 2012 Feb;97(2):349-54. doi: 10.1016/j. fertnstert.2011.11.017.

  69. Weghofer A, Klein K, Stammler-Safar M, Barad D, Worda C, Husslein P, et al. Severity of prematurity risk in spontaneous and in vitro fertilization twins: does conception mode serve as a risk factor? Fertil Steril. 2009 Dec;92(6):2116-8. doi: 10.1016/j. fertnstert.2009.05.087.

  70. Weghofer A, Klein K, Stammler-Safar M, Worda C, Barad D, Husslein P, et al. Can prematurity risk in twin pregnancies after in vitro fertilization be predicted? A retrospective study. Reprod Biol Endocrinol. 2009;7:136.

  71. Beydoun H, Ugwu B, and Oehninger S. Assisted reproduction for the validation of gestational age assessment methods. Reproductive BioMedicine Online. 2011;22:321-6. DOI:10.16/j.rbmo.2010.12.003

  72. Lee K. Fertility treatments and the cost of a healthy baby. Nursing for womens health. 2011;15(1):15-18.

  73. Barri P, Cololeu B, Clua E, Tur R. Prevention of prematurity by single embryo transfer. J Perinat Med. 2011;39:237-40. DOI 10.1515/JMP.2010.020

  74. Nelson S, Lawlor D. Predicting live birth, preterm delivery, and low birth weight in infants born from in vitro fertilization: A prospective study of 144,018 treatment cycles. Plos Med. 2011:8:e1000386

  75. Morcel K, Lavoue V, Beuchee A, Le lannou D, Poulain P, Pladys P. Perinatal morbidity and mortality in twin pregnancies with dichorionic placentas following assisted reproductive techniques or ovarian induction alone: a comparative study. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2010; 153:138-142.

  76. Chong CU, Huang LS, Lee TH, Liu CH, Shih YT, Lee MS. A comparison of the outcomes between twin and reduced twin pregnancies produced through assisted reproduction. Fertil Steril. 2007 Jul;88(1):47-52. DOI: 10.1016/j.fertnstert.2006.11.084.

  77. Ombelet W, Martens G, De-Sutter P, Gerris J, Bosmans E, Ruyssinck G, et al. Perinatal outcome of 12,021 singleton and 3,108 twin births after non- IVF-assisted reproduction: a cohort study. Hum Reprod. 2006 Apr;21(4):1025-32. DOI:10.1093/humrep/ dei419.

  78. Fenton TR. A new growth chart for preterm babies: Babson and Brenda’s chart updated with recent data and a new format. BMC Pediatr. 2003 Dec 16;3:13.




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