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ISSN 1405-1699 (Print)
Órgano Oficial del Colegio Mexicano de Alergia, Asma e Inmunología Pediátrica y de la Asociación Latinoamericana de Pediatría

2014, Number 1

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Alerg Asma Inmunol Pediatr 2014; 23 (1)

The comparison of clinical effect of immunotherapy in patients with allergic asthma by age and the pattern of sensitization

Sánchez J, Restrepo M, Diez S, Cardona R

Language: Spanish
References: 35
Page: 6-14
PDF size: 205.08 Kb.


ABSTRACT

Introduction: Allergen immunotherapy is a useful tool to control allergic asthma. There are no studies comparing if the starting age of immunotherapy significantly modified the clinical response. Objective: Investigate if the age of the onset in immunotherapy is a factor that modifies the therapeutic response. Methods: We compared the immunotherapy effect of reducing the number of exacerbations and the steroids and beta-agonist requirement, between patients with allergic asthma younger and older than 14 years of age during 18 months. Results: 64 patients with allergic asthma completed the study. Forty were polysensitized, 30 were children under 14 years. All patients had significant improvement in symptoms and a reduction in medication use (p ‹ 0.05), but patients under 14 years of age had a greater suspension of steroids and fewer respiratory exacerbations (p ‹ 0.05). The subgroup of patients monosensitized under 14 had the best response in all evaluated parameters. Conclusion: Even though, improvement was observed in all patients, the greatest impact was in children under 14 monosensitized; therefore, the immunotherapy should be performed early in the disease.


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