Mondragón-García I, Dircio-Maldonado R, Muñiz-Rivera-Cambas A, Corral-Navarro J, Mayani H

Language: Spanish
References: 22
Page: 36-43
PDF size: 189.51 Kb.

ABSTRACT

All blood cell types, that is to say, erythrocytes, leukocytes, and thrombocytes, originate from a common cell known as hematopoietic stem cell (HSC). The vast majority of HSC are localized in the bone marrow, where they correspond to 0.001% of the total cells in such a tissue. HSC are multipotent and capable of self-renewal, and sustain the whole hematopoietic system both under steady-state conditions and during physiological emergency. Hematopoietic cell transplants were first performed more than 50 years ago, and today they are a common practice for the treatment of leukemia and bone marrow failure. For such a transplant, hematopoietic cells can be obtained from bone marrow, mobilized peripheral blood or umbilical cord blood. During the last few years, several reports have presented evidence indicating that HSC can give rise to non-hematopoietic cells –including neural, muscle, and hepatic cells–, a property known as plasticity. Current research on HSC is focused on several biological aspects of such cells, and one of the most important relates to the development of experimental conditions for their in vitro expansion. It is hoped that such a research will allow, in the not too distant future, the use of HSC in cell therapy protocols.

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