Leal B, Fachín R, Aular L, Gómez F, Bosnjak M

Language: Spanish
References: 30
Page: 111-117
PDF size: 626.83 Kb.

ABSTRACT

Every living organism is mainly composed of water. Most biological membranes exhibit an increased permeability to water, which allows intra- and extracellular compartments to maintain the isotonicity required for intracellular homeostasis, although underlying mechanisms for this are still subject of debate. Water can cross the membranes through simple diffusion or by aqueous pores. While water transport was assumed to occur exclusively by the first mechanism, pioneer studies conducted through the sixties revealed otherwise, ultimately leading to the discovery by biologist Peter Agre of water channels or pores called Aquaporins. Aquaporins are a family of water-transporter homologous proteins expressed by epithelial, endothelial and other types of cells in mammals, which allowed a better understanding of the mechanisms used by the cell to control the flow of water through the membrane, and therefore, the regulation of its inner osmolarity. Aquaporin-3 (AQP3) is particularly important for its potential role in the treatment of skin conditions, since it may transport small organic molecules other than water, like glycerin or urea and may be stimulated selectively. This paper was intended to summarize the current knowledge on Aquaporins, with a particular emphasis on AQP3, and to delineate its possible future roles in Dermatology.

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